Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells.

Baumgartner, Marybeth; Olthof, Anouk M; Aquino, Gabriela S; Hyatt, Katery C; Lemoine, Christopher; Drake, Kyle; Sturrock, Nikita; Nguyen, Nhut; Al Seesi, Sahar; Kanadia, Rahul N

Baumgartner, Marybeth; Olthof, Anouk M; Aquino, Gabriela S; Hyatt, Katery C; Lemoine, Christopher; Drake, Kyle; Sturrock, Nikita; Nguyen, Nhut; Al Seesi, Sahar; Kanadia, Rahul N.

Afiliación

Baumgartner M; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Olthof AM; Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA.
Aquino GS; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Hyatt KC; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Lemoine C; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Drake K; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Sturrock N; College of Medicine, University of Illinois, Chicago, IL 60612, USA.
Nguyen N; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Al Seesi S; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.
Kanadia RN; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02115, USA.

Development ; 145(17)2018 08 28.

Article en En | MEDLINE | ID: mdl-30093551

Asunto(s)

Ciclo Celular/genética; Muerte Celular/fisiología; Enanismo/genética; Células Ependimogliales/metabolismo; Retardo del Crecimiento Fetal/genética; Microcefalia/genética; Células-Madre Neurales/citología; Osteocondrodisplasias/genética; Empalme del ARN/genética; ARN Nuclear Pequeño/genética; Empalmosomas/genética; Animales; Secuencia de Bases; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Empalmosomas/metabolismo; Proteína p53 Supresora de Tumor/biosíntesis

Palabras clave

Cell cycle; Cortical development; Microcephaly; Minor spliceosome; Radial glial cells; U11 snRNA

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteocondrodisplasias / ARN Nuclear Pequeño / Ciclo Celular / Empalme del ARN / Muerte Celular / Empalmosomas / Enanismo / Células-Madre Neurales / Retardo del Crecimiento Fetal / Células Ependimogliales Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google