Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP).

Rashid, Masturah Bte Mohd Abdul; Toh, Tan Boon; Hooi, Lissa; Silva, Aleidy; Zhang, Yanzhou; Tan, Pei Fang; Teh, Ai Ling; Karnani, Neerja; Jha, Sudhakar; Ho, Chih-Ming; Chng, Wee Joo; Ho, Dean; Chow, Edward Kai-Hua

Rashid, Masturah Bte Mohd Abdul; Toh, Tan Boon; Hooi, Lissa; Silva, Aleidy; Zhang, Yanzhou; Tan, Pei Fang; Teh, Ai Ling; Karnani, Neerja; Jha, Sudhakar; Ho, Chih-Ming; Chng, Wee Joo; Ho, Dean; Chow, Edward Kai-Hua.

Afiliación

Rashid MBMA; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Toh TB; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Hooi L; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Silva A; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Zhang Y; Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tan PF; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Teh AL; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Karnani N; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Jha S; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Ho CM; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Chng WJ; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Ho D; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Chow EK; Department of Mechanical Engineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Sci Transl Med ; 10(453)2018 08 08.

Article en En | MEDLINE | ID: mdl-30089632

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Mieloma Múltiple/tratamiento farmacológico; Animales; Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Bortezomib/farmacología; Bortezomib/uso terapéutico; Línea Celular Tumoral; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Daño del ADN; Metilación de ADN/genética; Decitabina/farmacología; Decitabina/uso terapéutico; Relación Dosis-Respuesta a Droga; Resistencia a Antineoplásicos/efectos de los fármacos; Resistencia a Antineoplásicos/genética; Sinergismo Farmacológico; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Genes Supresores de Tumor; Ensayos Analíticos de Alto Rendimiento; Humanos; Ratones; Mitomicina/farmacología; Mitomicina/uso terapéutico; Mieloma Múltiple/genética; Mieloma Múltiple/patología; Fenotipo; Proteína Tirosina Fosfatasa no Receptora Tipo 6/genética; Proteína Tirosina Fosfatasa no Receptora Tipo 6/metabolismo; ARN Mensajero/genética; ARN Mensajero/metabolismo; Carga Tumoral/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Mieloma Múltiple Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos

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