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Identification of a new European rabbit IgA with a serine-rich hinge region.
Pinheiro, Ana; de Sousa-Pereira, Patricia; Strive, Tanja; Knight, Katherine L; Woof, Jenny M; Esteves, Pedro J; Abrantes, Joana.
Afiliación
  • Pinheiro A; CIBIO Centro de Investigação em Biodiversidade e Recursos Genéticos, InBio Laboratório Associado, Universidade do Porto, Campus Agrário de Vairão, Vairão, Portugal.
  • de Sousa-Pereira P; CIBIO Centro de Investigação em Biodiversidade e Recursos Genéticos, InBio Laboratório Associado, Universidade do Porto, Campus Agrário de Vairão, Vairão, Portugal.
  • Strive T; Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
  • Knight KL; Max von Pettenkofer-Institute for Virology, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Woof JM; Commonwealth Scientific and Industrial Research Organization, Canberra, ACT, Australia.
  • Esteves PJ; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America.
  • Abrantes J; Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
PLoS One ; 13(8): e0201567, 2018.
Article en En | MEDLINE | ID: mdl-30089177
In mammals, the most striking IgA system belongs to Lagomorpha. Indeed, 14 IgA subclasses have been identified in European rabbits, 11 of which are expressed. In contrast, most other mammals have only one IgA, or in the case of hominoids, two IgA subclasses. Characteristic features of the mammalian IgA subclasses are the length and amino acid sequence of their hinge regions, which are often rich in Pro, Ser and Thr residues and may also carry Cys residues. Here, we describe a new IgA that was expressed in New Zealand White domestic rabbits of IGHVa1 allotype. This IgA has an extended hinge region containing an intriguing stretch of nine consecutive Ser residues and no Pro or Thr residues, a motif exclusive to this new rabbit IgA. Considering the amino acid properties, this hinge motif may present some advantage over the common IgA hinge by affording novel functional capabilities. We also sequenced for the first time the IgA14 CH2 and CH3 domains and showed that IgA14 and IgA3 are expressed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina / Cadenas alfa de Inmunoglobulina / Análisis de Secuencia de ARN / Análisis de Secuencia de ADN Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina / Cadenas alfa de Inmunoglobulina / Análisis de Secuencia de ARN / Análisis de Secuencia de ADN Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos