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The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review.
Ashaari, Zeinab; Hadjzadeh, Mousa-Al-Reza; Hassanzadeh, Gholamreza; Alizamir, Tahereh; Yousefi, Behpour; Keshavarzi, Zakieh; Mokhtari, Tahmineh.
Afiliación
  • Ashaari Z; Department of Physiology, School of Medicine, Mashhad University of Medicaid Sciences, Mashhad, Iran.
  • Hadjzadeh MA; Department of Physiology, School of Medicine, Mashhad University of Medicaid Sciences, Mashhad, Iran.
  • Hassanzadeh G; Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Alizamir T; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Yousefi B; Department of Anatomy, School of Medicine, Tehran University of Medicaid Sciences, Tehran, Iran.
  • Keshavarzi Z; Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mokhtari T; Nervous System Stem Cells Research Center, Semnan University of Medicaid Sciences, Semnan, Iran.
J Mol Neurosci ; 65(4): 491-506, 2018 Aug.
Article en En | MEDLINE | ID: mdl-30083786
Development and design of agents derived from natural sources with neuroprotective properties have received considerable attention. In the literature, it has been stated that these polyphenolic molecules have low adverse impacts and high efficacy when used in pathological conditions. Dietary flavonoids as a subgroup of polyphenols are bioactive products, extracted from several types of vegetables and fruits. Luteolin (3',4',5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway. Extensive in vitro and in vivo investigations have indicated that LUT exhibits beneficial neuroprotective properties via different mechanisms. However, its psychopharmacological mechanisms are presently investigated in fewer studies. Therefore, we aimed to evaluate the neuroprotective impacts of LUT against central nervous system (CNS) disorders by reviewing available literature. Herein, we also reviewed the studies to understand the underlying mechanisms of LUT for curing CNS disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Fármacos Neuroprotectores / Luteolina / Antioxidantes Límite: Animals / Humans Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Fármacos Neuroprotectores / Luteolina / Antioxidantes Límite: Animals / Humans Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos