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Predictors of short-term and long-term mortality in critically ill patients admitted to the intensive care unit following allogeneic stem cell transplantation.
van der Heiden, P L J; Arbous, M S; van Beers, E J; van den Bergh, W M; le Cessie, S; Demandt, A M P; Eefting, M; Hess, C; Kusadasi, N; Marijt, W A F; van Mook, W N K A; Müller, M C A; Tuinman, P R; van Vliet, M; van Westerloo, D J; Blijlevens, N M A.
Afiliación
  • van der Heiden PLJ; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands. P.L.J.van_der_Heiden@lumc.nl.
  • Arbous MS; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • van Beers EJ; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • van den Bergh WM; Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands.
  • le Cessie S; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Demandt AMP; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Eefting M; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
  • Hess C; Department of Hematology, Maastricht University Medical Center+, Maastricht, The Netherlands.
  • Kusadasi N; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
  • Marijt WAF; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Mook WNKA; Departement of Intensive Care Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Müller MCA; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
  • Tuinman PR; Department of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
  • van Vliet M; Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands.
  • van Westerloo DJ; Department of Intensive Care Medicine, VU university Medical Center, Amsterdam, The Netherlands.
  • Blijlevens NMA; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Bone Marrow Transplant ; 54(3): 418-424, 2019 03.
Article en En | MEDLINE | ID: mdl-30082850
Historically, the mortality of patients admitted to the ICU after allogeneic stem cell transplantation (alloSCT) is high. Advancements in transplantation procedures, infectious monitoring and supportive care may have improved the outcome. This study aimed to determine short-term and long-term mortality after ICU admission of patients after alloSCT and to identify prognostic clinical and transplantation-related determinants present at ICU admission for long-term outcome. A multicenter cohort study was performed to determine 30-day and 1-year mortality within 2 years following alloSCT. A total of 251 patients were included. The 30-day and 1-year mortality was 55% and 80%, respectively. Platelet count <25 × 109/L (OR: 2.26, CI: 1.02-5.01) and serum bilirubin >19 µmol/L (OR: 2.47 CI: 1.08-5.65) at admission, other donor than a HLA-matched-related or HLA-matched-unrelated donor (OR: 4.59, CI: 1.49-14.1) and vasoactive medication within 24 h (OR: 2.35, CI: 1.28-4.31) were associated with increased 30-day mortality. Other donor than a HLA-matched-related or HLA-matched-unrelated donor (OR: 1.9, CI: 1.13-3.19), serum bilirubin >77 (OR: 2.05, CI: 1.28-3.30) and vasoactive medication within 24 h (OR: 1.65, CI: 1.12-2.43) were associated with increased 1-year mortality. Neutropenia was associated with decreased 30-day and 1-year mortality (OR: 0.29, CI: 0.14-0.59 and OR: 0.70, CI: 0.48-0.98). Myeloablative conditioning and T cell-depleted transplantation were not associated with increased mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Homólogo / Enfermedad Crítica / Trasplante de Células Madre Hematopoyéticas / Acondicionamiento Pretrasplante / Unidades de Cuidados Intensivos Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Homólogo / Enfermedad Crítica / Trasplante de Células Madre Hematopoyéticas / Acondicionamiento Pretrasplante / Unidades de Cuidados Intensivos Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido