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Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease.
Jhun, Ellie H; Sadhu, Nilanjana; Yao, Yingwei; He, Ying; Molokie, Robert E; Wilkie, Diana J; Wang, Zaijie Jim.
Afiliación
  • Jhun EH; Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA.
  • Sadhu N; Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA.
  • Yao Y; Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, FL 32610, USA.
  • He Y; Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA.
  • Molokie RE; Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
  • Wilkie DJ; Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA.
  • Wang ZJ; Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
Pharmacogenomics ; 19(13): 1003-1011, 2018 08 01.
Article en En | MEDLINE | ID: mdl-30079801
AIM: Pain in sickle cell disease patients is heterogeneous and genetic polymorphisms may predispose an individual to varied vulnerability to painful events. We studied the association of SNPs in the glucocorticoid receptor gene (NR3C1) with pain in sickle cell disease. METHOD: Acute pain was scored as the number of utilizations due to crisis pain in a 12-month period. Chronic pain was calculated as the Composite Pain Index score. RESULTS & CONCLUSION: rs33389 T allele (IRR = 1.53, p = 0.014 additive; IRR = 1.64, p = 0.011 recessive), rs2963155 G allele (IRR = 1.80, p < 0.001 additive; IRR = 2.25, p = 0.021 dominant; IRR = 2.07, p < 0.001 recessive) and rs9324918 C allele (IRR = 1.43, p = 0.021 additive) were associated with higher utilization rates, indicating the potential contribution of NR3C1 polymorphisms to acute pain heterogeneity in sickle cell disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Glucocorticoides / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Dolor Agudo / Anemia de Células Falciformes Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Glucocorticoides / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Dolor Agudo / Anemia de Células Falciformes Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido