Your browser doesn't support javascript.
loading
Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.
Laganà, Antonio Simone; Vitagliano, Amerigo; Noventa, Marco; Ambrosini, Guido; D'Anna, Rosario.
Afiliación
  • Laganà AS; Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, Piazza Biroldi 1, 21100, Varese, Italy. antlagana@unime.it.
  • Vitagliano A; Department of Woman and Child Health, University of Padua, Padua, Italy.
  • Noventa M; Department of Woman and Child Health, University of Padua, Padua, Italy.
  • Ambrosini G; Department of Woman and Child Health, University of Padua, Padua, Italy.
  • D'Anna R; Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Arch Gynecol Obstet ; 298(4): 675-684, 2018 10.
Article en En | MEDLINE | ID: mdl-30078122
PURPOSE: To evaluate whether oral myo-inositol supplementation (MI) is able to reduce the amount of gonadotropins (GA) and the length of controlled ovarian hyperstimulation (SL) in both Polycystic Ovarian Syndrome (PCOS) and non-PCOS women undergoing in vitro fertilization (IVF). METHODS: We performed a systematic review (PROSPERO ID: CRD42017069439) of randomized controlled trials (RCTs). We searched articles published in English between January 1985 to August 2017, using the combination of the Medical Subject Headings "Inositol" with "Ovulation Induction", "follicle-stimulating hormone, human, with HCG C-terminal peptide", "Reproductive Techniques, Assisted", and "Fertilization in Vitro". We collected data about GA and SL comparing MI to no treatment or D-Chiro-Inositol (DCI) supplementation (controls). A subgroup analysis was performed to evaluate selected outcomes in PCOS and non-PCOS women. RESULTS: We included 8 studies embedding 812 participants. We found a reduction in GA (p < 0.00001) and SL (p = 0.0007) in patients receiving MI with respect to controls. MI was effective in both PCOS (p < 0.00001) and non-PCOS women (p = 0.02) in reducing GA; conversely, MI supplementation decreased the SL only in PCOS women (p < 0.00001). CONCLUSION: During IVF, MI is effective in both PCOS and non-PCOS women in saving gonadotropins, but reduces efficiently SL only in PCOS women.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inducción de la Ovulación / Síndrome del Ovario Poliquístico / Fertilización In Vitro / Gonadotropinas / Inositol Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inducción de la Ovulación / Síndrome del Ovario Poliquístico / Fertilización In Vitro / Gonadotropinas / Inositol Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania