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IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease.
Cakmak Genc, Gunes; Dursun, Ahmet; Karakas Celik, Sevim; Calik, Mustafa; Kokturk, Furuzan; Piskin, Ibrahim Etem.
Afiliación
  • Cakmak Genc G; Faculty of Medicine, Department of Medical Genetics, Bulent Ecevit University, Zonguldak, Turkey. Electronic address: gunes.cak@hotmail.com.
  • Dursun A; Faculty of Medicine, Department of Medical Genetics, Bulent Ecevit University, Zonguldak, Turkey.
  • Karakas Celik S; Faculty of Sciences and Arts, Department of Molecular Biology and Genetics, Bulent Ecevit University, Zonguldak, Turkey.
  • Calik M; Faculty of Medicine, Department of Pediatric Neurology, Harran University, Sanliurfa, Turkey.
  • Kokturk F; Faculty of Medicine, Department of Biostatistics, Bulent Ecevit University, Zonguldak, Turkey.
  • Piskin IE; Faculty of Medicine, Department of Pediatrics, Bulent Ecevit University, Zonguldak, Turkey.
Gene ; 678: 73-78, 2018 Dec 15.
Article en En | MEDLINE | ID: mdl-30077763
Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disease which affects children and young adults, caused by a persistent infection of defective measles virus. IFN-λs (IL-28A, IL-28B and IL-29) are a group of cytokines mediating antiviral responses. It has been shown that IL-29 levels are significantly higher in infected cells with defective measles virus. IL-29 expression is thought to be regulated at post-transcriptional level and miRNA-548 family targets the 3'UTR of the IFNL1 gene. Impaired immune system has an important role as well as viral factors in SSPE. The aim of our study investigates whether IL-28B, IL-29 levels and gene polymorphisms contribute to the damaged immune response leading to the development of SSPE. Also possible association of miR-548 family with IL-29 and SSPE is explored. Frequencies of rs12979860, rs8099917, rs30461, serum levels of IL-28B, IL-29 and expression levels of miR-548b, miR-548c, miR-548i are determined at 64 SSPE patients and 68 healthy controls. Serum IL-29 levels are statistically significant higher in SSPE patients. Allele frequencies of rs8099917 are statistically significant higher in SSPE patients and resulted G allele is found to increase 2.183-fold risk of SSPE. The expression levels of miR-548b-5p, miR-548c-5p and miR-548i are found to be statistically significant higher in SSPE patients. Dramatically increased level of IL-29 seen in patient group indicates that the elevated miR-548 expression is compensatory result of the over-activated immune system response. Further studies referred to IL28, IL29 and related miRNA's will be enlightened the pathogenesis of SSPE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panencefalitis Esclerosante Subaguda / Interleucinas / Enfermedades Raras / MicroARNs Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panencefalitis Esclerosante Subaguda / Interleucinas / Enfermedades Raras / MicroARNs Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos