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Monoamine Oxidase B in Renal Cell Carcinoma.
Hodorová, Ingrid; Rybárová, Silvia; Solár, Peter; Benický, Marián; Rybár, Dusan; Kovácová, Zuzana; Mihalik, Jozef.
Afiliación
  • Hodorová I; Department of Anatomy, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
  • Rybárová S; Department of Anatomy, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
  • Solár P; Department of Medical Biology, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
  • Benický M; Department of Pathology, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
  • Rybár D; Department of Anesthesiology and Intensive Medicine, P.J. Safárik University, Faculty of Medicine and VUSCH a.s., Kosice, Slovakia.
  • Kovácová Z; Department of Anatomy, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
  • Mihalik J; Department of Anatomy, P.J. Safárik University, Faculty of Medicine, Kosice, Slovakia.
Med Sci Monit ; 24: 5422-5426, 2018 Aug 04.
Article en En | MEDLINE | ID: mdl-30076780
BACKGROUND Studies on monoamine oxidase B (MAO-B) expression in renal cell carcinoma (RCC) are lacking. This study focused on the immunohistochemical evaluation of MAO-B in RCC. MATERIAL AND METHODS Sixty-three RCC samples were compared on basic clinical and histopathological parameters, including histopathological type and tumor grade. RCC samples were divided according to the histopathological type into 2 groups: conventional type (51 samples) and other types (12 samples). For MAO-B detection, a standard immunohistochemical procedure was employed. RESULTS In healthy kidney samples, MAO-B was detected predominantly in tubules. Fifty-two cancer tissue samples were MAO-B negative and 11 tissue samples were MAO-B low positive. Enzymes were detected only in the cytoplasm. We did not find any significant correlation between the percentage of positive MAO-B specimens and nuclear grade. Additionally, Fisher's test did not reveal any difference in numbers of positive and negative MAO-B samples between the 2 RCC types (P>0.05). CONCLUSIONS From our results, it was clear that MAO-B expression played no significant role in stimulation of renal cancer development. We found that MAO-B occurred only in 19% of kidney tumors and that the positivity of protein expression was low. Moreover, it seems that the disappearance of this enzyme in RCC is a consequence of replacement of healthy tissue by cancer cells. On the other hand, one can assume that the loss of MAO-B expression could be associated with severe pathological processes in the kidney.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Monoaminooxidasa Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Monoaminooxidasa Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Estados Unidos