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Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity.
Woods, Gina N; Ewing, Susan K; Sigurdsson, Sigurdur; Kado, Deborah M; Ix, Joachim H; Hue, Trisha F; Eiriksdottir, Gudny; Xu, Kaipin; Gudnason, Vilmundur; Lang, Thomas F; Vittinghoff, Eric; Harris, Tamara B; Rosen, Clifford J; Li, Xiaojuan; Schwartz, Ann V.
Afiliación
  • Woods GN; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Ewing SK; VA San Diego Healthcare System, San Diego, CA, USA.
  • Sigurdsson S; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
  • Kado DM; Icelandic Heart Association, Kopavogur, Iceland.
  • Ix JH; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Hue TF; Department of Family Medicine & Public Health, University of California, San Diego, La Jolla, CA, USA.
  • Eiriksdottir G; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Xu K; VA San Diego Healthcare System, San Diego, CA, USA.
  • Gudnason V; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
  • Lang TF; Icelandic Heart Association, Kopavogur, Iceland.
  • Vittinghoff E; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.
  • Harris TB; Icelandic Heart Association, Kopavogur, Iceland.
  • Rosen CJ; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Li X; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
  • Schwartz AV; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
J Bone Miner Res ; 33(12): 2158-2164, 2018 12.
Article en En | MEDLINE | ID: mdl-30075054
Bone marrow adiposity is associated with aging, osteoporosis, and reduced hematopoiesis, as well as anorexia nervosa, but little is known about the underlying mechanisms that affect marrow adiposity. Chronic kidney disease (CKD) may influence bone marrow adipose tissue (BMAT), possibly through loss of lean mass or higher circulating levels of sclerostin. To test these hypotheses, we investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) as a measure of kidney function and 1 H-MRS-based measurement of vertebral BMAT (L1 to L4) in 475 older adults from the Age Gene/Environment Susceptibility (AGES)-Reykjavik study. Mean BMAT was compared in those with eGFR >60 (n = 297) versus those with eGFR 45 to 60 (n = 120) or eGFR <45 (n = 58) using linear regression models. Participants had a mean age of 81.5 (SD 4.1) years, mean eGFR of 64.3 (SD 16.1) mL/min/1.734 cm2 , mean BMAT of 54.5% (SD 8.5); 48.2% were women. In unadjusted and adjusted models (age, visit window, gender, diabetes and visceral adipose tissue), BMAT was higher in those with eGFR <45 (adjusted mean 58.5%; 95% CI, 56.2 to 60.7) compared with those with eGFR >60 (adjusted mean 53.8%; 95% CI, 52.8 to 54.8) (p = 0.0002). BMAT did not differ in those with eGFR 45 to 60 (adjusted mean 54.3%; 95% CI, 52.8 to 55.9) compared with those with eGFR >60 (p = 0.58). In a subgroup of participants with serum sclerostin available (n = 253), additional adjustment for sclerostin attenuated the difference in adjusted mean vertebral BMAT between those with eGFR <45 versus >60 from 3.7% (p = 0.04) to 2.4% (p = 0.20). CKD stage 3b or worse was associated with greater bone marrow adiposity; this association may be partially mediated by sclerostin. © 2018 American Society for Bone and Mineral Research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Insuficiencia Renal Crónica / Adiposidad Tipo de estudio: Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Insuficiencia Renal Crónica / Adiposidad Tipo de estudio: Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos