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Cytotoxicity of Different Concentrations of Three Root Canal Sealers on Human Mesenchymal Stem Cells.
Alsubait, Sara A; Al Ajlan, Reem; Mitwalli, Hala; Aburaisi, Nour; Mahmood, Amer; Muthurangan, Manikandan; Almadhri, Randa; Alfayez, Musaad; Anil, Sukumaran.
Afiliación
  • Alsubait SA; Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11611, Saudi Arabia. salsubait@ksu.edu.sa.
  • Al Ajlan R; College of Dentistry, King Saud University, P.O. Box 85676, Riyadh 11611, Saudi Arabia. reem-alajlan@hotmail.com.
  • Mitwalli H; College of Dentistry, King Saud University, P.O. Box 85676, Riyadh 11611, Saudi Arabia. hala.mitwalli@gmail.com.
  • Aburaisi N; College of Dentistry, King Saud University, P.O. Box 85676, Riyadh 11611, Saudi Arabia. noursamer92@gmail.com.
  • Mahmood A; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. ammahmood@ksu.edu.sa.
  • Muthurangan M; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. coralmani@gmail.com.
  • Almadhri R; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. r.i.almadhri@gmail.com.
  • Alfayez M; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. alfayez@ksu.edu.sa.
  • Anil S; Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha University, Poonamallee High Road, Chennai 600077, India. drsanil@gmail.com.
Biomolecules ; 8(3)2018 08 01.
Article en En | MEDLINE | ID: mdl-30071665
This study assessed the dose-dependent effect on the cytotoxicity of BioRoot RCS (BR) and Endosequence BC (BC) sealers in human bone marrow mesenchymal stem cells (hMSCs) compared to those of the AH Plus sealer. Cells were exposed to different dilutions of extracts from freshly prepared sealers (1:2, 1:8, 1:32). Unexposed cells acted as the negative control. Cytotoxicity was evaluated by an alamar blue assay. Cell morphology was analyzed by using scanning electron microscopy after exposure to the different sealers' extracts. Statistical analysis was performed using a one-way analysis of variance and the Bonferroni post hoc test (p < 0.05). The cytotoxicities of BC and BR were less than that of AH Plus. In the presence of 1:2 BR, the cell proliferation was significantly lower than the control. At 1:8 and 1:32 concentrations, both the tricalcium silicate sealers led to similar cellular proliferation. Cells in BC and BR sealers' extracts spread better than those in AH Plus extract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cemento de Óxido de Zinc-Eugenol / Citotoxinas / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Biomolecules Año: 2018 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cemento de Óxido de Zinc-Eugenol / Citotoxinas / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: Biomolecules Año: 2018 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza