Your browser doesn't support javascript.
loading
Mutational landscape and clonal diversity of pulmonary adenoid cystic carcinoma.
Li, Min; Zhao, Bing-Rong; Liu, Shi-Qing; An, Jian; Deng, Peng-Bo; Han-Zhang, Han; Ye, Jun-Yi; Mao, Xin-Ru; Chuai, Shao-Kun; Hu, Cheng-Ping.
Afiliación
  • Li M; a Department of Respiratory Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • Zhao BR; b Center for Molecular Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • Liu SQ; a Department of Respiratory Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • An J; a Department of Respiratory Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • Deng PB; a Department of Respiratory Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • Han-Zhang H; a Department of Respiratory Medicine , Xiangya Hospital, Central South University , Changsha , China.
  • Ye JY; c Burning Rock Biotech , Guangzhou , China.
  • Mao XR; c Burning Rock Biotech , Guangzhou , China.
  • Chuai SK; c Burning Rock Biotech , Guangzhou , China.
  • Hu CP; c Burning Rock Biotech , Guangzhou , China.
Cancer Biol Ther ; 19(10): 898-903, 2018.
Article en En | MEDLINE | ID: mdl-30067437
Pulmonary adenoid cystic carcinoma is a rare and indolent lung malignancy, characterized by a protracted but unpredictable growth behavior. Currently, the treatment of PACC relies on surgery and local radiotherapy. However, treatment options for advanced PACC patients are limited. A larger number of studies demonstrated that advanced PACC patients obtained limited benefit from chemotherapy. Moreover, only a few case reports revealed PACC patients were candidates for target therapy. Therefore, there is an urgent need to develop novel therapies. Due to its rareness, its mutational landscape remains largely elusive. In this study, we performed capture-based ultra-deep sequencing on multiregional surgical specimens obtained from 8 PACC patients using a panel consisting of 295 cancer-related genes. Our data revealed distinctive mutational spectrum of PACC, which differed from non-small cell lung cancer and adenoid cystic carcinomas originated from other anatomical sites. PACC, lacking mutations in a majority of non-small cell lung cancer driver genes, has frequent mutations in genes participating in chromatin remodeling and NOTCH signaling pathway. We also elucidated spatial intra-tumoral heterogeneity, which varied among cases. Most mutations in chromatin remodelers were subclonal. Collectively, our findings elucidated molecular signature associated with PACC and highlighted the potential for epigenetic therapy in this disease.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Adenoide Quístico / Heterogeneidad Genética / Evolución Clonal / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Biol Ther Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Adenoide Quístico / Heterogeneidad Genética / Evolución Clonal / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Biol Ther Asunto de la revista: NEOPLASIAS / TERAPEUTICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos