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Economic burden of hospital admissions for patients with acute bacterial skin and skin structure infections in the United States.
Keyloun, Katelyn R; Weber, David J; Gardstein, Betsey M; Berger, Ariel; Gillard, Patrick; Ganz, Michael L.
Afiliación
  • Keyloun KR; a Global Health Economics & Outcomes Research , Allergan plc , Irvine , CA , USA.
  • Weber DJ; b Infectious Diseases , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
  • Gardstein BM; c Real-World Evidence , Evidera , Waltham , MA , USA.
  • Berger A; c Real-World Evidence , Evidera , Waltham , MA , USA.
  • Gillard P; a Global Health Economics & Outcomes Research , Allergan plc , Irvine , CA , USA.
  • Ganz ML; c Real-World Evidence , Evidera , Waltham , MA , USA.
Hosp Pract (1995) ; 46(5): 278-286, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30067108
Objectives: We estimated the total US hospital costs associated with acute bacterial skin and skin structure infection (ABSSSI) admissions as well as the admissions that may have been potential candidates for outpatient parenteral antimicrobial therapy (OPAT). Methods: We assessed inpatient admissions for ABSSSI from the Premier database (2011-2014), focusing on all admissions of adults with length of stay (LOS) ≥ 1 days and a primary diagnosis of erysipelas, cellulitis/abscess, or wound infection. We performed a detailed analysis of 2014 admissions for patient, treatment, hospital, and economic characteristic variables. Using published selection criteria, we identified a subset of patients admitted in 2014 who may have been potential candidates for OPAT. Results: We analyzed 277,971 admissions. In 2014, most admissions were for cellulitis without major complications or comorbidities; mean ± SD LOS was 4.0 ± 3.0 days, and total hospital cost per admission was $6400 ± $6874, 54% of which was attributable to room costs. Among 2014 admissions, 14% involved patients with clinical characteristics suggesting that they were consistent with guideline recommendations for exclusive treatment with OPAT. Compared with all admissions in the year, these admissions were of younger patients (aged 50 vs. 55 years), admitted more frequently for cellulitis (90% vs. 70%), with shorter LOS (2.8 ± 1.8 days), and lower mean total hospital cost per admission ($4080 ± $3066). Conclusions: Admissions for ABSSSI impose a substantial cost to US hospitals, with half of costs attributable to room costs. When extrapolated to all US patients admitted to the hospital for ABSSSI during 2014, had OPAT guidelines been universally followed, admissions may have been reduced by 14%, thereby saving US hospitals $161 million.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cutáneas Bacterianas / Costos de Hospital / Hospitalización / Antibacterianos Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Hosp Pract (1995) Asunto de la revista: HOSPITAIS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cutáneas Bacterianas / Costos de Hospital / Hospitalización / Antibacterianos Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Hosp Pract (1995) Asunto de la revista: HOSPITAIS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido