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Bariatric surgery in obese patients reduced resting connectivity of brain regions involved with self-referential processing.
Li, Guanya; Ji, Gang; Hu, Yang; Xu, Mingzhu; Jin, Qingchao; Liu, Li; von Deneen, Karen M; Zhao, Jizheng; Chen, Antao; Cui, Guangbin; Wang, Huaning; Zhao, Qingchuan; Wu, Kaichun; Shokri-Kojori, Ehsan; Tomasi, Dardo; Volkow, Nora D; Nie, Yongzhan; Zhang, Yi; Wang, Gene-Jack.
Afiliación
  • Li G; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Ji G; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Hu Y; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Xu M; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Jin Q; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Liu L; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • von Deneen KM; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Zhao J; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Chen A; College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
  • Cui G; Department of Psychology, Southwest University, Chongqing, China.
  • Wang H; Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Zhao Q; Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Wu K; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Shokri-Kojori E; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Tomasi D; Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
  • Volkow ND; Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
  • Nie Y; Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
  • Zhang Y; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Wang GJ; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
Hum Brain Mapp ; 39(12): 4755-4765, 2018 12.
Article en En | MEDLINE | ID: mdl-30062852
Obese individuals exhibit brain alterations of resting-state functional connectivity (RSFC) integrity of resting-state networks (RSNs) related to food intake. Bariatric surgery is currently the most effective treatment for combating morbid obesity. How bariatric surgery influences neurocircuitry is mostly unknown. Functional connectivity density (FCD) mapping was employed to calculate local (lFCD)/global (gFCD) voxelwise connectivity metrics in 22 obese participants who underwent functional magnetic resonance imaging before and 1 month after sleeve gastrectomy (SG), and in 19 obese controls (Ctr) without surgery but tested twice (baseline and 1-month later). Two factor (group, time) repeated measures ANOVA was used to assess main and interaction effects in lFCD/gFCD; regions of interest were identified for subsequent seed to voxel connectivity analyses to assess resting-state functional connectivity and to examine association with weight loss. Bariatric surgery significantly decreased lFCD in VMPFC, posterior cingulate cortex (PCC)/precuneus, and dorsal anterior cingulate cortex (dACC)/dorsomedial prefrontal cortex (DMPFC) and decreased gFCD in VMPFC, right dorsolateral prefrontal cortex (DLPFC) and right insula (pFWE < .05). lFCD decreased in VMPFC and PCC/precuneus correlated with reduction in BMI after surgery. Seed to voxel connectivity analyses showed the VMPFC had stronger connectivity with left DLPFC and weaker connectivity with hippocampus/parahippocampus, and PCC/precuneus had stronger connectivity with right caudate and left DLPFC after surgery. Bariatric surgery significantly decreased FCD in regions involved in self-referential processing (VMPFC, DMPFC, dACC, and precuneus), and interoception (insula), and changes in VMPFC/precuneus were associated with reduction in BMI suggesting a role in improving control of eating behaviors following surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Corteza Cerebral / Ego / Cirugía Bariátrica / Función Ejecutiva / Conectoma / Red Nerviosa Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Corteza Cerebral / Ego / Cirugía Bariátrica / Función Ejecutiva / Conectoma / Red Nerviosa Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos