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Salivary shedding of herpesviruses in renal transplant recipients.
Sarmento, Dmitry José de Santana; Caliento, Rubens; Souza, Amabile Oliveira de; Tozetto-Mendoza, Tânia Regina; Palmieri, Michelle; Martins, Victor Adriano de Oliveira; Braz-Silva, Paulo Henrique; Gallottini, Marina.
Afiliación
  • Sarmento DJS; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Caliento R; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Souza AO; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Tozetto-Mendoza TR; Institute of Tropical Medicine of São Paulo, Univerity of São Paulo, São Paulo, Brazil.
  • Palmieri M; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Martins VAO; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Braz-Silva PH; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Gallottini M; Institute of Tropical Medicine of São Paulo, Univerity of São Paulo, São Paulo, Brazil.
J Investig Clin Dent ; 9(4): e12356, 2018 Nov.
Article en En | MEDLINE | ID: mdl-30062730
AIM: The aim of the present study was to describe the salivary shedding of human herpesviruses (HHV) in renal transplant recipients and to observe the oral manifestations in this group. METHODS: A prospective case-control study was conducted with a study group of 20 renal transplant recipients and a control group of 20 non-transplanted, immunocompetent individuals. Clinical examination evaluated the presence of drug-induced gingival overgrowth (DIGO), salivary flow, and caries. Stimulated saliva was collected from both groups, with HHV being detected by using real-time polymerase chain reaction. RESULTS: The mean age of the study group was 45.90 ± 9.89 years, with 55% (11/20) being female, 60% (12/20) being Caucasian, 65% (13/20) having a deceased donor, and 70% (14/20) having used tacrolimus as the main immunosuppressive drug. Renal transplant recipients had shedding of more herpesviruses compared to the control group, with the exception of HHV-7. Statistical significance was found for herpes simplex virus-1 (HSV-1) (P = 0.017) and cytomegalovirus (P = 0.035). DIGO was observed in seven patients (35%), with 35% (7/20) presenting with decreased salivary flow and four (20%) reporting xerostomia. CONCLUSION: Renal transplant recipients excreted herpesviruses more often than control individuals, especially HSV-1. Decreased salivary flow and xerostomia were more frequent in patients who used tacrolimus, whereas those who used cyclosporine had more cases of DIGO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Trasplante de Riñón / Infecciones por Herpesviridae / Herpesviridae Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Investig Clin Dent Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Trasplante de Riñón / Infecciones por Herpesviridae / Herpesviridae Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Investig Clin Dent Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Australia