Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.

Sharp, Thomas E; Kubo, Hajime; Berretta, Remus M; Starosta, Timothy; Wallner, Markus; Schena, Giana J; Hobby, Alexander R; Yu, Daohai; Trappanese, Danielle M; George, Jon C; Molkentin, Jeffery D; Houser, Steven R

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.

Sharp, Thomas E; Kubo, Hajime; Berretta, Remus M; Starosta, Timothy; Wallner, Markus; Schena, Giana J; Hobby, Alexander R; Yu, Daohai; Trappanese, Danielle M; George, Jon C; Molkentin, Jeffery D; Houser, Steven R.

Afiliación

Sharp TE; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Kubo H; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Berretta RM; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Starosta T; Department Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Wallner M; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Schena GJ; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Hobby AR; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Yu D; Department of Clinical Sciences, Temple Clinical Research Institute, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Trappanese DM; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
George JC; Cardiovascular Research Center, Department of Physiology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Molkentin JD; Department of Cardiology, Temple University Hospital, Philadelphia, Pennsylvania.
Houser SR; Department of Pediatrics and Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

JACC Basic Transl Sci ; 2(6): 669-683, 2017 Dec.

Article en En | MEDLINE | ID: mdl-30062182

Palabras clave

ADHF, acute decompensated heart failure; DIG, digitalis; DOB, dobutamine; ECG, electrocardiogram; EDPVR, end-diastolic pressure-volume relationship; EDV, end-diastolic volume; ESPVR, end-systolic pressure-volume relationship; ESV, end-systolic volume; Ees, elastance end-systole; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; IR, ischemiareperfusion; LAD, left anterior descending coronary artery; LV, left ventricle/ventricular; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVVPed10, left ventricular end-diastolic volume at a pressure of 10 mm Hg; LVVPes80, left ventricular end- systolic volume at a pressure of 80 mm Hg; MI, myocardial infarction; PKA, protein kinase A; PKC, protein kinase C; PKCα/ß inhibitor; PLN, phospholamban; PRSW, pre-load recruitable stroke work; RBX, ruboxistaurin; acute myocardial infarction; heart failure with reduced ejection fraction; invasive hemodynamics; positive inotropy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

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