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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Li, Xiaodun; Francies, Hayley E; Secrier, Maria; Perner, Juliane; Miremadi, Ahmad; Galeano-Dalmau, Núria; Barendt, William J; Letchford, Laura; Leyden, Genevieve M; Goffin, Emma K; Barthorpe, Andrew; Lightfoot, Howard; Chen, Elisabeth; Gilbert, James; Noorani, Ayesha; Devonshire, Ginny; Bower, Lawrence; Grantham, Amber; MacRae, Shona; Grehan, Nicola; Wedge, David C; Fitzgerald, Rebecca C; Garnett, Mathew J.
Afiliación
  • Li X; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.
  • Francies HE; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Secrier M; Cancer Research UK Cambridge Institute, Cambridge, CB2 0RE, UK.
  • Perner J; Oncology IMED, AstraZeneca, Chesterford, Cambridge, CB10 1XL, UK.
  • Miremadi A; Cancer Research UK Cambridge Institute, Cambridge, CB2 0RE, UK.
  • Galeano-Dalmau N; Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK.
  • Barendt WJ; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.
  • Letchford L; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Leyden GM; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Goffin EK; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Barthorpe A; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Lightfoot H; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Chen E; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Gilbert J; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Noorani A; Wellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Devonshire G; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.
  • Bower L; Cancer Research UK Cambridge Institute, Cambridge, CB2 0RE, UK.
  • Grantham A; Cancer Research UK Cambridge Institute, Cambridge, CB2 0RE, UK.
  • MacRae S; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.
  • Grehan N; MRC Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK.
  • Wedge DC; Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK.
  • Fitzgerald RC; Big Data Institute, University of Oxford, Oxford, OX3 7LF, UK.
  • Garnett MJ; Oxford NIHR Biomedical Research Centre, Oxford, OX4 2PG, UK.
Nat Commun ; 9(1): 2983, 2018 07 30.
Article en En | MEDLINE | ID: mdl-30061675
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Adenocarcinoma / Organoides / Proteínas Tirosina Quinasas Receptoras / Evolución Clonal Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Adenocarcinoma / Organoides / Proteínas Tirosina Quinasas Receptoras / Evolución Clonal Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido