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Intratumoral Accumulation and Clonal Expansion May Not Be Decisive for Rejection of Allogeneic Tumors by CD8+ T-Lymphocytes.
Jursenaite, Jurgita; Girkontaite, Irute; Siaurys, Almantas; Mauricas, Mykolas; Characiejus, Dainius.
Afiliación
  • Jursenaite J; Department of Immunology, Centre for Innovative Medicine, Vilnius, Lithuania.
  • Girkontaite I; Department of Immunology, Centre for Innovative Medicine, Vilnius, Lithuania.
  • Siaurys A; Department of Immunology, Centre for Innovative Medicine, Vilnius, Lithuania.
  • Mauricas M; Department of Immunology, Centre for Innovative Medicine, Vilnius, Lithuania.
  • Characiejus D; Department of Immunology, Centre for Innovative Medicine, Vilnius, Lithuania dainius.characiejus@gmail.com.
Anticancer Res ; 38(8): 4481-4484, 2018 Aug.
Article en En | MEDLINE | ID: mdl-30061213
BACKGROUND: The aim of this study was to analyze the spatial distribution and proliferation of adoptively transferred CD8+ T-lymphocytes sensitized against allogeneic tumors. MATERIALS AND METHODS: Transgenic ß-actin-luc mice that express luciferase were sensitized against allogeneic SL2 lymphoma. CD8+ T-lymphocytes from these mice were transferred to lymphocyte-deficient, recombination activating gene-deficient (Rag-/-) mice bearing SL2 tumors and were tracked using bioluminescence imaging. RESULTS: Two out of six Rag-/- mice rejected their tumors. There were no apparent differences in spatial distribution and proliferative intensity of adoptively-transferred CD8+ T-lymphocytes between the two Rag-/- mice that rejected allogeneic SL2 tumors and the four Rag-/- mice that did not. CONCLUSION: The pattern of distribution in the mouse body and proliferative intensity of CD8+ T-lymphocytes do not seem to be decisive factors influencing allogeneic tumor rejection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Rechazo de Injerto / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anticancer Res Año: 2018 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Rechazo de Injerto / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anticancer Res Año: 2018 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Grecia