Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations.

Elion, David L; Cook, Rebecca S

Elion, David L; Cook, Rebecca S.

Afiliación

Elion DL; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: Rebecca.cook@vanderbilt.edu.

Trends Mol Med ; 24(8): 655-656, 2018 08.

Article en En | MEDLINE | ID: mdl-30060834

RESUMEN

Chemotherapy is the most commonly prescribed treatment for patients with aggressive and lethal triple negative breast cancers (TNBCs), which often develop chemoresistance. A recent study combined single nucleus sequencing, single cell RNA sequencing, and evolutionary biology to understand how tumor cells use genetic and phenotypic diversity to evade the selective pressures of neoadjuvant chemotherapy.

Asunto(s)

Neoplasias de la Mama Triple Negativas; Protocolos de Quimioterapia Combinada Antineoplásica; Resistencia a Antineoplásicos; Humanos; Terapia Neoadyuvante

Palabras clave

chemotherapy; clonal tumor cell subpopulations; intratumoral heterogeneity; pathological complete response; transcriptional reprogramming; triple negative breast cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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