Your browser doesn't support javascript.
loading
30-Year Longitudinal Study of Hematological Parameters of HIV-1 Negative Men Participating in Los Angeles Multicenter AIDS Cohort Study (MACS).
Aziz, Najib; Quint, Joshua J; Breen, Elizabeth C; Oishi, John; Jamieson, Beth D; Martinez-Maza, Otoniel; Detels, Roger.
Afiliación
  • Aziz N; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
  • Quint JJ; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
  • Breen EC; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Oishi J; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
  • Jamieson BD; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Martinez-Maza O; Department of Obstetrics & Gynecology, Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Detels R; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
Lab Med ; 50(1): 64-72, 2019 Jan 01.
Article en En | MEDLINE | ID: mdl-30060104
BACKGROUND: Clinicians often use population-based reference intervals (RIs) when interpreting patient results. However, this method can present problems if the analyte in question has wide variability from person to person. METHODS: We examined the biological variation of routine hematologic markers in 82 white non-Hispanic men every 6 months during a 30-year period, to determine the usefulness of population-based RIs and age-related decline of hematological markers. RESULTS: Many of these markers showed significant person-to-person differences (index of individuality <1.4 in 10/11 markers) and change over time with a decrease in mean for white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, and neutrophils. The mean increased for monocytes, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) (all P <.05). CONCLUSION: Longitudinal analysis demonstrated significant decline in hematologic marker counts, with the exception of MCV and MCH. Establishment of a personalized baseline for hematologic assessments may be more useful to clinicians than previous methods.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Inmunodeficiencia Adquirida / Seronegatividad para VIH / Pruebas Hematológicas Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Lab Med Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Inmunodeficiencia Adquirida / Seronegatividad para VIH / Pruebas Hematológicas Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Lab Med Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido