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Obstructive sleep apnea in children with Marfan syndrome: Relationships between three-dimensional palatal morphology and apnea-hypopnea index.
Paoloni, V; Cretella Lombardo, E; Placidi, F; Ruvolo, G; Cozza, P; Laganà, G.
Afiliación
  • Paoloni V; Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: vamapa87@gmail.com.
  • Cretella Lombardo E; Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Placidi F; Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Ruvolo G; Department of Cardiac Surgery Unit, Centre for Rare Diseases for Marfan Syndrome and Related Disorders, University of Tor Vergata General Hospital, Rome, Italy.
  • Cozza P; Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Laganà G; Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Int J Pediatr Otorhinolaryngol ; 112: 6-9, 2018 Sep.
Article en En | MEDLINE | ID: mdl-30055741
OBJECTIVE: To evaluate the relationship between the severity degree of OSA (apnea/hypopnea index AHI>1) and palatal area and volume, measured by 3D analysis of digital casts in Marfan children. METHODS: Twenty children with a clinical diagnosis of MS were recruited from a tertiary medical center. All the subjects underwent standard nocturnal polygraphy testing. Sixteen Marfan patients (7F,9 M; mean age 8.8yy ±â€¯1.5yy) with AHI>1 were enrolled. Marfan Group (MG) was compared with a control group (CG) of 17 children without Marfan syndrome (9F,8 M; mean age 8.5yy ±â€¯1.7yy) presenting with nose-breathing pattern. For each subject maxillary digital casts were taken and palatal area and volume were measured. Unpaired t-test was used to test significant differences between MG and CG for area and volume measurements. Pearson correlation coefficient (PCC) was used to measure the linear correlation between the degree of OSA (AHI index) and palatal volume and palatal area. RESULTS: 80% of Marfan children presented an AHI>1 and a diagnosis of OSA. MG presented statistically significant lower values of palatal surface area (662.68 mm2; P < 0.0001) and palatal volume (2578.1 mm3; P < 0.0001) with respect to CG (923.0 mm2 and 3756.6 mm3, respectively). Correlation analysis showed that AHI index had no linear correlation with palatal area (r = - 0,07) and with palatal volume (r = - 0,11). CONCLUSION: OSA is highly prevalent in children with Marfan's syndrome (80%). Marfan children present a reduction of palatal area and volume when compared to healthy subjects. OSA in Marfan children is not linear correlated to the palatal morphology and it shows a multifactorial aetiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hueso Paladar / Índice de Severidad de la Enfermedad / Apnea Obstructiva del Sueño / Síndrome de Marfan Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Int J Pediatr Otorhinolaryngol Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hueso Paladar / Índice de Severidad de la Enfermedad / Apnea Obstructiva del Sueño / Síndrome de Marfan Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Int J Pediatr Otorhinolaryngol Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda