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Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model.
Eastwood, Mary Patrice; Daamen, Willeke F; Joyeux, Luc; Pranpanus, Savitree; Rynkevic, Rita; Hympanova, Lucie; Pot, Michiel W; Hof, Danique J; Gayan-Ramirez, Ghislaine; van Kuppevelt, Toin H; Verbeken, Eric; Deprest, Jan.
Afiliación
  • Eastwood MP; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Daamen WF; Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Joyeux L; Department of Biochemistry, RIMLS, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Pranpanus S; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Rynkevic R; Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Hympanova L; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Pot MW; Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Hof DJ; Department of Obstetrics and Gynecology, Prince of Songkla University, Hat Yai, Thailand.
  • Gayan-Ramirez G; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
  • van Kuppevelt TH; NEGI, Faculdade de Engenharia da Universidade do Porto, Universidade do Porto, Porto, Portugal.
  • Verbeken E; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Deprest J; Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium.
J Tissue Eng Regen Med ; 12(11): 2138-2150, 2018 11.
Article en En | MEDLINE | ID: mdl-30055525
Gore-Tex® is a widely used durable patch for repair of congenital diaphragmatic defects yet may result in complications. We compared Gore-Tex with a composite of a radial pore-orientated collagen scaffold (RP-Composite) and clinically used porcine small intestinal submucosa (SIS; Surgisis®) in a rabbit model for diaphragmatic hernia. The growing rabbit mimics the rapid rib cage growth and reherniation rates seen in children. We created and immediately repaired left hemidiaphragmatic defects in 6-week-old rabbits with Gore-Tex, SIS, and an RP-Composite scaffold. An additional group of rabbits had a sham operation. At 90 days, survivors more than doubled in weight. We observed few reherniations or eventrations in Gore-Tex (17%) and RP-Composite (22%) implanted animals. However, SIS failed in all rabbits. Maximum transdiaphragmatic pressure was lower in Gore-Tex (71%) than RP-Composite implanted animals (112%) or sham (134%). Gore-Tex repairs were less compliant than RP-Composite, which behaved as sham diaphragm (p < 0.01). RP-Composite induced less foreign body giant cell reaction than Gore-Tex (p < 0.05) with more collagen deposition (p < 0.001), although there was a tendency for the scaffold to calcify. Unlike Gore-Tex, the compliance of diaphragms reconstructed with RP-Composite scaffolds were comparable with native diaphragm, whereas reherniation rates and transdiaphragmatic pressure measurements were similar.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Andamios del Tejido / Herniorrafia / Hernia Diafragmática Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Tissue Eng Regen Med Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Andamios del Tejido / Herniorrafia / Hernia Diafragmática Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: J Tissue Eng Regen Med Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido