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Role of properdin in complement-mediated kidney diseases.
van Essen, Mieke F; Ruben, Jurjen M; de Vries, Aiko P J; van Kooten, Cees.
Afiliación
  • van Essen MF; Division of Nephrology and Transplant Medicine, Department Of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • Ruben JM; Division of Nephrology and Transplant Medicine, Department Of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • de Vries APJ; Division of Nephrology and Transplant Medicine, Department Of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • van Kooten C; Division of Nephrology and Transplant Medicine, Department Of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Nephrol Dial Transplant ; 34(5): 742-750, 2019 05 01.
Article en En | MEDLINE | ID: mdl-30053164
As part of the innate immune system, the complement system is an important mechanism in our first line of defence, but it can also contribute to the onset of various diseases. In renal diseases, the dysregulation of the complement system is often caused by mutations in-and autoantibodies directed against-members of the complement system, and contributes to disease onset and severity. As the only known positive regulator of the complement system, the role of properdin in complement-mediated diseases is largely unknown. In this review, we provide an overview of the detection of properdin in kidney biopsies and urine, serum or plasma samples from patients with complement-mediated renal diseases, such as immune complex-mediated glomerulonephritis and C3 glomerulopathy. Advances towards a better understanding of the role of properdin in (local) complement activation will provide insight into its potential role and offer opportunities to improve diagnosis and therapeutic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Properdina / Activación de Complemento / Inmunidad Innata / Enfermedades Renales Límite: Humans Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Properdina / Activación de Complemento / Inmunidad Innata / Enfermedades Renales Límite: Humans Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido