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The habu genome reveals accelerated evolution of venom protein genes.
Shibata, Hiroki; Chijiwa, Takahito; Oda-Ueda, Naoko; Nakamura, Hitomi; Yamaguchi, Kazuaki; Hattori, Shousaku; Matsubara, Kazumi; Matsuda, Yoichi; Yamashita, Akifumi; Isomoto, Akiko; Mori, Kazuki; Tashiro, Kosuke; Kuhara, Satoru; Yamasaki, Shinichi; Fujie, Manabu; Goto, Hiroki; Koyanagi, Ryo; Takeuchi, Takeshi; Fukumaki, Yasuyuki; Ohno, Motonori; Shoguchi, Eiichi; Hisata, Kanako; Satoh, Noriyuki; Ogawa, Tomohisa.
Afiliación
  • Shibata H; Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan. hshibata@gen.kyushu-u.ac.jp.
  • Chijiwa T; Graduate School of Systems Life Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, 812-8581, Japan. hshibata@gen.kyushu-u.ac.jp.
  • Oda-Ueda N; Department of Applied Life Science, Faculty of Bioscience and Biotechnology, Sojo University, Kumamoto, 860-0082, Japan.
  • Nakamura H; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, 860-0082, Japan.
  • Yamaguchi K; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, 860-0082, Japan.
  • Hattori S; Department of Applied Life Science, Faculty of Bioscience and Biotechnology, Sojo University, Kumamoto, 860-0082, Japan.
  • Matsubara K; Institute of Medical Science, University of Tokyo, Oshima-gun, Kagoshima, 894-1531, Japan.
  • Matsuda Y; Department of Information and Biological Sciences, Graduate School of Natural Sciences, Nagoya City University, Nagoya, Aichi, 467-0802, Japan.
  • Yamashita A; Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, 464-8601, Japan.
  • Isomoto A; Department of Biomolecular Science, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, 980-8577, Japan.
  • Mori K; Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
  • Tashiro K; Graduate School of Systems Life Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, 812-8581, Japan.
  • Kuhara S; Graduate School of Systems Life Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, 812-8581, Japan.
  • Yamasaki S; Computational Bio-Big Data Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, Shinjuku-ku, Tokyo, 169-0072, Japan.
  • Fujie M; Graduate School of Systems Life Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, 812-8581, Japan.
  • Goto H; Graduate School of Systems Life Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, 812-8581, Japan.
  • Koyanagi R; DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
  • Takeuchi T; DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
  • Fukumaki Y; DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
  • Ohno M; DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
  • Shoguchi E; Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
  • Hisata K; Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
  • Satoh N; Department of Applied Life Science, Faculty of Bioscience and Biotechnology, Sojo University, Kumamoto, 860-0082, Japan.
  • Ogawa T; Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Sci Rep ; 8(1): 11300, 2018 07 26.
Article en En | MEDLINE | ID: mdl-30050104
Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Serpiente / Trimeresurus / Evolución Molecular / Proteínas de Reptiles Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Serpiente / Trimeresurus / Evolución Molecular / Proteínas de Reptiles Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido