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Screening for frailty among older patients with cancer using blood biomarkers of inflammation.
Harneshaug, Magnus; Kirkhus, Lene; Benth, Jurate Saltyte; Grønberg, Bjørn Henning; Bergh, Sverre; Whist, Jon Elling; Rostoft, Siri; Jordhøy, Marit S.
Afiliación
  • Harneshaug M; The Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, P.O. Box 68, 2313 Ottestad, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 4956, Nydalen, 0424 Oslo, Norway. Electronic address: Magnus.Harneshaug@sykehuset-innlandet.no.
  • Kirkhus L; The Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, P.O. Box 68, 2313 Ottestad, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 4956, Nydalen, 0424 Oslo, Norway. Electronic address: Lene.Kirkhus@sykehuset-innlandet.no.
  • Benth JS; The Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, P.O. Box 68, 2313 Ottestad, Norway; HØKH Research Centre, Akershus University Hospital, P.O. Box 1000, 1478 Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, P.O. Box 1171, 0318 Blinderen, Norway.
  • Grønberg BH; The Cancer Clinic, St. Olav's Hospital, Trondheim University Hospital, P.O. Box 3250, Sluppen, 7006 Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, P.O. Box 8905, 7491 Trondheim, Norway.
  • Bergh S; The Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, P.O. Box 68, 2313 Ottestad, Norway; Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Norway. Electronic address: Sverre.Bergh@sykehuset-innlandet.no.
  • Whist JE; The Department of Research, Innlandet Hospital Trust, P.O. Box 104, 2381 Brumunddal, Norway; Laboratory of Medical Biochemistry, Innlandet Hospital Trust, P.O. 2381, Brumunddal, Norway. Electronic address: Jon.Elling.Whist@sykehuset-innlandet.no.
  • Rostoft S; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 4956, Nydalen, 0424 Oslo, Norway; Department of Geriatric Medicine, Oslo University Hospital, P.O. Box 4956, Nydalen, 0424 Oslo, Norway.
  • Jordhøy MS; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 4956, Nydalen, 0424 Oslo, Norway; The Cancer Unit, Innlandet Hospital Trust, Hamar Hospital, Skolegata 32, 2326 Hamar, Norway.
J Geriatr Oncol ; 10(2): 272-278, 2019 03.
Article en En | MEDLINE | ID: mdl-30049582
INTRODUCTION: As frailty is associated with inflammation, biomarkers of inflammation may represent objective measures that could facilitate the identification of frailty. Glasgow prognostic score (GPS), combines C-reactive protein (CRP) and albumin, and is scored from 0 to 2 points. Higher score indicates a higher degree of inflammation. OBJECTIVES: To investigate whether (1) GPS is associated with frailty, (2) GPS could be used to screen for frailty, (3) IL-6 and TNF-α add to the accuracy of GPS as a screening tool, and (4) GPS adds prognostic information in frail older patients with cancer. METHODS: Prospective, observational study of 255 patients ≥70 years with solid malignant tumours referred for medical cancer treatment. At baseline, frail patients were identified by a modified Geriatric Assessment (mGA), and blood samples were collected. RESULTS: Mean age was 76.7 years, 49.8% were frail, and 56.1% had distant metastases. The proportion of frail patients increased with higher GPS (GPS zero: 43.2%, GPS one: 52.7%, GPS two: 94.7%). GPS two was significantly associated with frailty (OR 18.5), independent of cancer type, stage, BMI and the use of anti-inflammatory drugs. The specificity of GPS was high (99%), but the sensitivity was low (14%). Frail patients with GPS two had poorer survival than patients with GPS zero-one. TNF-α and IL-6 did not improve the accuracy of GPS when screening for frailty. CONCLUSION: Frailty and GPS two are strongly associated, and GPS two is a significant prognostic factor in frail, older patients with cancer. The inflammatory biomarkers investigated are not suitable screening tools for frailty.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Albúmina Sérica / Interleucina-6 / Factor de Necrosis Tumoral alfa / Fragilidad / Inflamación / Neoplasias Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Geriatr Oncol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Albúmina Sérica / Interleucina-6 / Factor de Necrosis Tumoral alfa / Fragilidad / Inflamación / Neoplasias Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Geriatr Oncol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos