Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.

Walkup, Ward G; Sweredoski, Michael J; Graham, Robert L; Hess, Sonja; Kennedy, Mary B

Walkup, Ward G; Sweredoski, Michael J; Graham, Robert L; Hess, Sonja; Kennedy, Mary B.

Afiliación

Walkup WG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA; De Novo Discovery Group, FogPharma, Cambridge, MA, 02140, USA. Electronic address: wwalkup@alumni.caltech.edu.
Sweredoski MJ; Proteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, CA, 91125, USA.
Graham RL; Proteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, CA, 91125, USA; Institute of Cancer Sciences, Faculty of Medical and Human Sciences, University of Manchester, M13 9PL, UK.
Hess S; Proteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, CA, 91125, USA; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA.
Kennedy MB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Biochem Biophys Res Commun ; 503(3): 1599-1604, 2018 09 10.

Article en En | MEDLINE | ID: mdl-30049443

Asunto(s)

Proteínas Activadoras de GTPasa/metabolismo; Proteínas Serina-Treonina Quinasas/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Proteínas de Unión al GTP rap/metabolismo; Proteínas de Unión al GTP rap1/metabolismo; Animales; Células COS; Chlorocebus aethiops; Humanos; Espectrometría de Masas; Fosforilación

Palabras clave

Cyclin-dependent kinase 5 (CDK5); Polo-like kinase 2 (Plk2); Postsynaptic density; Synaptic GTPase activating protein (synGAP); Synaptic plasticity; Synaptic scaling

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Proteínas Serina-Treonina Quinasas / Proteínas de Unión al GTP rap / Proteínas de Unión al GTP rap1 / Proteínas Activadoras de GTPasa Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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