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Infant and childhood growth and frailty in old age: the Helsinki Birth Cohort Study.
Haapanen, M J; Perälä, M M; Osmond, C; Salonen, M K; Kajantie, E; Rantanen, T; Simonen, M; Pohjolainen, P; Eriksson, J G; von Bonsdorff, M B.
Afiliación
  • Haapanen MJ; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, PO Box 20, 00014, Helsinki, Finland. markus.haapanen@helsinki.fi.
  • Perälä MM; Folkhälsan Research Center, Helsinki, Finland. markus.haapanen@helsinki.fi.
  • Osmond C; Folkhälsan Research Center, Helsinki, Finland.
  • Salonen MK; Chronic Disease Prevention Unit, Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
  • Kajantie E; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southamptom, Southampton, UK.
  • Rantanen T; Folkhälsan Research Center, Helsinki, Finland.
  • Simonen M; Chronic Disease Prevention Unit, Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
  • Pohjolainen P; Chronic Disease Prevention Unit, Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
  • Eriksson JG; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
  • von Bonsdorff MB; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Aging Clin Exp Res ; 31(5): 717-721, 2019 May.
Article en En | MEDLINE | ID: mdl-30043315
BACKGROUND: Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. METHODS: In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. RESULTS: Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. CONCLUSIONS: Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desarrollo Infantil / Fragilidad Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desarrollo Infantil / Fragilidad Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Alemania