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Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane.
Salnikov, Oleg G; Kovtunov, Kirill V; Nikolaou, Panayiotis; Kovtunova, Larisa M; Bukhtiyarov, Valerii I; Koptyug, Igor V; Chekmenev, Eduard Y.
Afiliación
  • Salnikov OG; International Tomography Center, SB RAS, 3 A Institutskaya st., Novosibirsk, 630090, Russia.
  • Kovtunov KV; Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090, Russia.
  • Nikolaou P; International Tomography Center, SB RAS, 3 A Institutskaya st., Novosibirsk, 630090, Russia.
  • Kovtunova LM; Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090, Russia.
  • Bukhtiyarov VI; Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, and Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Medical Center, Nashville, TN, 37232-2310, United States.
  • Koptyug IV; Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090, Russia.
  • Chekmenev EY; Boreskov Institute of Catalysis, SB RAS, 5 Acad. Lavrentiev pr., Novosibirsk, 630090, Russia.
Chemphyschem ; 19(20): 2621-2626, 2018 10 19.
Article en En | MEDLINE | ID: mdl-30039565
Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton-hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non-toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1 H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR-invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR-visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C-H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciclopropanos / Hidrógeno Idioma: En Revista: Chemphyschem Asunto de la revista: BIOFISICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciclopropanos / Hidrógeno Idioma: En Revista: Chemphyschem Asunto de la revista: BIOFISICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Alemania