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A network map of thrombopoietin signaling.
Bhat, Firdous A; Advani, Jayshree; Khan, Aafaque Ahmad; Mohan, Sonali; Pal, Arnab; Gowda, Harsha; Chakrabarti, Prantar; Keshava Prasad, T S; Chatterjee, Aditi.
Afiliación
  • Bhat FA; Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
  • Advani J; School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India.
  • Khan AA; Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
  • Mohan S; Manipal Academy of Higher Education, Manipal, 576104, India.
  • Pal A; Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
  • Gowda H; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, 751024, India.
  • Chakrabarti P; Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
  • Keshava Prasad TS; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
  • Chatterjee A; Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
J Cell Commun Signal ; 12(4): 737-743, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30039510
Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a cytokine involved in the production of platelets. THPO is a glycoprotein produced by liver and kidney. It regulates the production of platelets by stimulating the differentiation and maturation of megakaryocyte progenitors. It acts as a ligand for MPL receptor, a member of the hematopoietic cytokine receptor superfamily and is essential for megakaryocyte maturation. THPO binding induces homodimerization of the receptor which results in activation of JAKSTAT and MAPK signaling cascades that subsequently control cellular proliferation, differentiation and other signaling events. Despite the importance of THPO signaling in various diseases and biological processes, a detailed signaling network of THPO is not available in any publicly available database. Therefore, in this study, we present a resource of signaling events induced by THPO that was manually curated from published literature on THPO. Our manual curation of thrombopoietin pathway resulted in identification of 48 molecular associations, 66 catalytic reactions, 100 gene regulation events, 19 protein translocation events and 43 activation/inhibition reactions that occur upon activation of thrombopoietin receptor by THPO. THPO signaling pathway is made available on NetPath, a freely available human signaling pathway resource developed previously by our group. We believe this resource will provide a platform for scientific community to accelerate further research in this area on potential therapeutic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: J Cell Commun Signal Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: J Cell Commun Signal Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos