Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2.

Mercurio, Flavia Anna; Pirone, Luciano; Di Natale, Concetta; Marasco, Daniela; Pedone, Emilia Maria; Leone, Marilisa

Mercurio, Flavia Anna; Pirone, Luciano; Di Natale, Concetta; Marasco, Daniela; Pedone, Emilia Maria; Leone, Marilisa.

Afiliación

Mercurio FA; Institute of Biostructures and Bioimaging (CNR), Naples, Italy; InterUniversity Research Centre on Bioactive Peptides (CIRPEB), University of Naples Federico II, Naples, Italy.
Pirone L; Institute of Biostructures and Bioimaging (CNR), Naples, Italy; InterUniversity Research Centre on Bioactive Peptides (CIRPEB), University of Naples Federico II, Naples, Italy.
Di Natale C; University of Naples Federico II, Department of Pharmacy, Naples, Italy.
Marasco D; Institute of Biostructures and Bioimaging (CNR), Naples, Italy; InterUniversity Research Centre on Bioactive Peptides (CIRPEB), University of Naples Federico II, Naples, Italy; University of Naples Federico II, Department of Pharmacy, Naples, Italy.
Pedone EM; Institute of Biostructures and Bioimaging (CNR), Naples, Italy; InterUniversity Research Centre on Bioactive Peptides (CIRPEB), University of Naples Federico II, Naples, Italy.
Leone M; Institute of Biostructures and Bioimaging (CNR), Naples, Italy; InterUniversity Research Centre on Bioactive Peptides (CIRPEB), University of Naples Federico II, Naples, Italy. Electronic address: marilisa.leone@cnr.it.

Bioorg Chem ; 80: 602-610, 2018 10.

Article en En | MEDLINE | ID: mdl-30036816

Asunto(s)

Péptidos/química; Péptidos/farmacología; Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas/metabolismo; Mapas de Interacción de Proteínas/efectos de los fármacos; Receptor EphA2/metabolismo; Secuencia de Aminoácidos; Descubrimiento de Drogas; Humanos; Modelos Moleculares; Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas/química; Unión Proteica/efectos de los fármacos; Receptor EphA2/química; Motivo alfa Estéril/efectos de los fármacos

Palabras clave

Cancer; EphA2; PPI inhibitors; Sam domains; Stapled peptides

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Receptor EphA2 / Mapas de Interacción de Proteínas / Fosfatidilinositol-3,4,5-Trifosfato 5-Fosfatasas Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

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