Your browser doesn't support javascript.
loading
[Practical approach to patient therapy affected by Autosomal Dominant Autosomic Polycystic Kidney Disease].
Esposito, Ciro; La Milia, Vincenzo; Altobelli, Claudia; Cerutti, Roberta; Manunta, Paolo; Dallera, Nadia; Piscopo, Giovanni; Magistroni, Riccardo.
Afiliación
  • Esposito C; Nefrologia e Dialisi, ICS Maugeri S.p.A. SB, Università di Pavia, Pavia, Italia.
  • La Milia V; Nefrologia e Dialisi, Ospedale di Lecco, Italia.
  • Altobelli C; Università degli Studi della Campania Luigi Vanvitelli, U.O.C. di Nefrologia e Dialisi, Napoli, Italia.
  • Cerutti R; Nefrologia e Dialisi della Fondazione IRCCS Policlinico, Mangiagalli, Regina Elena, Milano, Italia.
  • Manunta P; Università Vita Salute San Raffaele, Istituto Scientifico San Raffale, Milano, Italia.
  • Dallera N; Nefrologia e Dialisi, Presidio Ospedaliero Montichiari, Brescia, Italia.
  • Piscopo G; Azienda Ospedaliero Universitaria Consorziale Policlinico e Università degli Studi Aldo Moro di Bari.
  • Magistroni R; Divisione di Nefrologia, Dialisi Azienda Ospedaliero Universitaria Policlinico di Modena, Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa. Università di Modena e Reggio Emilia, Modena, Italia.
G Ital Nefrol ; 35(4)2018 Jul.
Article en It | MEDLINE | ID: mdl-30035441
The Autosomal Dominant Polycystic Kidney Disease(ADPKD) is the most frequent renal genetic condition and involves 7 to 10% of subjects undergoing renal replacement therapy. It is estimated that between 24,000 and 34,000 subjects in Italy are affected by this condition. For an illness that has long been neglected due to a lack of treatment options, an attractive treatment possibility is now available: tolvaptan has shown clinical efficacy regarding disease progression in two clinical trials (ADPKD patients with mild renal failure and ADPKD patients with advanced renal failure). The possible liver toxicity expressed in about 4% of the subjects exposed to the drug and an important aquaretic effect suggest prudence and attention in the use of this new molecule. Based on these critical points, some clinicians with direct experience in the use of the drug have briefly collected in the pages to follow the main clinical recommendations for the treatment of ADPKD patints. The recommendations concern the general approach to the patient affected by ADPKD but with particular attention to the aspects related to the new treatment. The delicate task of introducing the opportunities and limitations of the offered therapy to the patient will be deepened. Finally, the document wants to suggest how best to organize a clinic dedicated to this condition.
Asunto(s)
Palabras clave
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón Poliquístico Autosómico Dominante / Antagonistas de los Receptores de Hormonas Antidiuréticas / Tolvaptán Tipo de estudio: Guideline Límite: Humans Idioma: It Revista: G Ital Nefrol Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón Poliquístico Autosómico Dominante / Antagonistas de los Receptores de Hormonas Antidiuréticas / Tolvaptán Tipo de estudio: Guideline Límite: Humans Idioma: It Revista: G Ital Nefrol Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia