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In vitro and in vivo evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition.
Park, Dae Sung; Bae, In-Ho; Jeong, Myung Ho; Lim, Kyung Seob; Sim, Doo Sun; Hong, Young Joon; Lee, So-Youn; Jang, Eun Jae; Shim, Jae-Won; Park, Jun-Kyu; Lim, Han Chul; Kim, Han Byul.
Afiliación
  • Park DS; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea; Research Institute of Medical Sciences, Chonn
  • Bae IH; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea.
  • Jeong MH; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea; Department of Cardiology, Chonnam National Un
  • Lim KS; Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 28116, Chungbuk, Republic of Korea.
  • Sim DS; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
  • Hong YJ; Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
  • Lee SY; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea.
  • Jang EJ; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea.
  • Shim JW; The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Republic of Korea; Korea Cardiovascular Stent Research Institute, Jangsung 57248, Republic of Korea.
  • Park JK; Department of Polymer Science and Engineering, Sunchon National University, Suncheon 57922, Republic of Korea.
  • Lim HC; Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
  • Kim HB; Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
Mater Sci Eng C Mater Biol Appl ; 91: 615-623, 2018 Oct 01.
Article en En | MEDLINE | ID: mdl-30033294
Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO2) and verify its efficacy by in vitro and in vivo assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO2 stent, everolimus-eluting N-TiO2 (N-TiO2-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO2 film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO2 deposition (37.0%). The platelet adhesion on the N-TiO2 surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO2-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO2-EVL group compared to that in the BMS group. The results (BMS; 47.0 ±â€¯11.00%, N-TiO2-EVL; 31.7 ±â€¯10.50%, and EES; 29.1 ±â€¯11.21%, n = 10, p < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO2 deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Titanio / Stents Liberadores de Fármacos / Everolimus / Nitrógeno Límite: Animals Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Titanio / Stents Liberadores de Fármacos / Everolimus / Nitrógeno Límite: Animals Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos