Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project.

de Melo E Silva, Daniela; Alves, Alessandro Arruda; Nunes, Hugo Freire; Ramos, Jheneffer Sonara Aguiar; Franco, Fernanda Craveiro; Soares, Thannya Nascimento

de Melo E Silva, Daniela; Alves, Alessandro Arruda; Nunes, Hugo Freire; Ramos, Jheneffer Sonara Aguiar; Franco, Fernanda Craveiro; Soares, Thannya Nascimento.

Afiliación

de Melo E Silva D; Laboratório de Mutagênese, Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. danielamelosilva@ufg.br.
Alves AA; Depto. de Genética. Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, ICB I - Sala 218/228. Bairro: Campus Universitário, Goiânia, GO, CEP: 74690-900, Brazil. danielamelosilva@ufg.br.
Nunes HF; Laboratório de Mutagênese, Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
Ramos JSA; Laboratório de Mutagênese, Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
Franco FC; Laboratório de Mutagênese, Departamento de Genética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
Soares TN; Laboratório de Virologia e Cultura Celular, Departamento de Microbiologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.

Environ Sci Pollut Res Int ; 25(25): 25612-25617, 2018 Sep.

Article en En | MEDLINE | ID: mdl-30030761

RESUMEN

Brazilian population is one of the largest consumers of pesticides in the world, especially the Central Brazil population. Thus, the aim of this study was to evaluate the frequency of genotypes, alleles, haplotypes, and the linkage disequilibrium (DL) of the OGG1 gene in rural workers from Central Brazil, comparing with the populations of the 1000 genome. Three hundred thirty healthy individuals not related and randomly selected were included in this study. We obtained genomic DNA from peripheral blood lymphocytes. The 748-bp OGG1 gene was amplified by PCR and sequenced. Of the 330 individuals, 215 (65%) were males and 115 (35%) were females. There were no differences in the distribution of the rs1052133 and rs293795 with age and sexes. Haplotypes containing only conserved T/C alleles were the most common in our population. The frequency of the mutant alleles of rs1052133 and rs293795, in our population, was 20% and 30%, respectively, and it is noteworthy, worldwide, that mutant alleles are commonly associated to an increased risk for the development of cancer, specially due to direct or indirect contact to pesticides, as occurs in rural workers of Central Brazil population.

Asunto(s)

ADN Glicosilasas/genética; Polimorfismo de Nucleótido Simple; Población Rural; Adulto; Alelos; Brasil; Femenino; Haplotipos; Humanos; Masculino; Persona de Mediana Edad

Palabras clave

Central Brazil; Distribution; Genotype; Pesticides; Repair; Risk population

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural / Polimorfismo de Nucleótido Simple / ADN Glicosilasas Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania

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