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An investigation of the association between the level of prolactin in serum and type II diabetes.
Manshaei, Najmeh; Shakibaei, Feloria; Fazilati, Mohammad; Salavati, Hossein; Negahdary, Masoud; Palizban, Abbasali.
Afiliación
  • Manshaei N; Department of Biochemistry, Payame Noor University, Isfahan, Iran.
  • Shakibaei F; Department of Biochemistry, Payame Noor University, Isfahan, Iran.
  • Fazilati M; Department of Biochemistry, Payame Noor University, Isfahan, Iran.
  • Salavati H; Department of Biochemistry, Payame Noor University, Isfahan, Iran.
  • Negahdary M; Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: masoudnegahdary@ssu.ac.ir.
  • Palizban A; Department of Clinical Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: palizban@pharm.mui.ac.ir.
Diabetes Metab Syndr ; 13(5): 3035-3041, 2019.
Article en En | MEDLINE | ID: mdl-30030156
As a hormone secreted from the pituitary gland, prolactin (PRL) plays an important role in increasing beta cell proliferation, stimulating the secretion of insulin, preventing the activities of caspases on pathways that cause apoptosis in the Langerhans' islands, and moderating the immune system in regulating the whole body's sensitivity to insulin. Therefore, PRL level changes in type II diabetes and it can be concluded that PRL can play an important role in metabolic disorders of glucose. The present study is carried out in order to investigate the association between serum levels of PRL and type II DM. Blood samples were taken from 64 females affected by type II diabetes and 70 healthy ones, whose PRL level was measured using electrochemiluminescence (ECL) technique. It was a case-control study, and based on the definition dedicated to each group, subjects were assigned to two groups. The patient group included the subjects with type II diabetes while the control group included healthy samples. Data were analyzed using SPSS software (Mann-Whitney test, t-test, and spearman's rho correlation test). According to the results, PRL concentration in the serum of people affected by type II diabetes (5.32 ±â€¯0.36) was significantly (P˂0.05) lower than that of control group (18.38 ±â€¯2.3). The results also showed that in type II diabetes, the level of PRL changes so that the concentration of PRL in the serum of the patients was lower than that of healthy ones. Therefore, PRL concentration in the blood can be related to diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Biomarcadores / Diabetes Mellitus Tipo 2 Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Diabetes Metab Syndr Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Biomarcadores / Diabetes Mellitus Tipo 2 Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Diabetes Metab Syndr Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos