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Differential gene expression to an LPS challenge in relation to exogenous corticosterone in the invasive cane toad (Rhinella marina).
Gardner, Steven; Assis, Vania Regina; Zhao, Honggang; Gomes, Fernando Ribeiro; Peatman, Eric; Mendonça, Mary T.
Afiliación
  • Gardner S; Department of Biological Sciences, Auburn University, 331 Funchess Hall, 350 South College St, Auburn, AL 36849, USA. Electronic address: stg0015@tigermail.auburn.edu.
  • Assis VR; Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, Rua do Matão, trav. 14, 101, 05508-900, São Paulo, SP, Brazil. Electronic address: v.regina.a@ib.usp.br.
  • Zhao H; School of Fisheries, Aquaculture, and Aquatic Sciences, 377 CASIC Bldg, Auburn University, Auburn, AL 36849, USA. Electronic address: hzz0024@tigermail.auburn.edu.
  • Gomes FR; Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, Rua do Matão, trav. 14, 101, 05508-900, São Paulo, SP, Brazil. Electronic address: frgomes@usp.br.
  • Peatman E; School of Fisheries, Aquaculture, and Aquatic Sciences, 377 CASIC Bldg, Auburn University, Auburn, AL 36849, USA. Electronic address: peatmer@auburn.edu.
  • Mendonça MT; Department of Biological Sciences, Auburn University, 331 Funchess Hall, 350 South College St, Auburn, AL 36849, USA. Electronic address: mendomt@auburn.edu.
Dev Comp Immunol ; 88: 114-123, 2018 11.
Article en En | MEDLINE | ID: mdl-30030104
The cane toad (Rhinella marina) is an invasive amphibian in several parts of the world. Much of the research performed on assessing the dispersal potential of invasive species has focused immunity. Invaders are predicted to rely less on pro-inflammatory immunity, allowing them to allocate energy to dispersal. Elevated stress may play a role in regulation of immune responses used by invasive species. RNA sequencing of spleen tissue from cane toads subjected to an acute LPS challenge revealed genes coding for cytokines involved in typical innate responses such as phagocytic cell recruitment, extravasation, inflammation, and lymphocyte differentiation were significantly upregulated, while toads receiving transdermal application of corticosterone in addition to an LPS injection showed downregulation of genes involved with cell mediated immunity. These results indicate hormonal changes associated with acute stress may alter investment into mounting cell-mediated or humoral responses while allowing for prolonged phagocytic innate responses in this invasive species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bufo marinus / Lipopolisacáridos / Proteínas Anfibias / Especies Introducidas Límite: Animals Idioma: En Revista: Dev Comp Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bufo marinus / Lipopolisacáridos / Proteínas Anfibias / Especies Introducidas Límite: Animals Idioma: En Revista: Dev Comp Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos