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Measurement of urea and creatinine in saliva of dogs: a pilot study.
Tvarijonaviciute, Asta; Pardo-Marin, Luis; Tecles, Fernando; Carrillo, Juana Dolores; Garcia-Martinez, Juan Diego; Bernal, Luis; Pastor, Josep; Cerón, José J; Martinez-Subiela, Silvia.
Afiliación
  • Tvarijonaviciute A; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
  • Pardo-Marin L; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
  • Tecles F; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
  • Carrillo JD; From the Department of Animal Medicine and Surgery, School of Veterinary Medicine, University of Murcia, Murcia, Spain.
  • Garcia-Martinez JD; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
  • Bernal L; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
  • Pastor J; From the Animal Medicine and Surgery Department, School of Veterinary Medicine, University Autonomous of Barcelona, Barcelona, Spain.
  • Cerón JJ; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain. jjceron@um.es.
  • Martinez-Subiela S; From the Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Campus of Espinardo s/n, 30100, Murcia, Spain.
BMC Vet Res ; 14(1): 223, 2018 Jul 20.
Article en En | MEDLINE | ID: mdl-30029662
BACKGROUND: Urea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva, and to evaluate their possible changes in situations of CKD. RESULTS: The spectrophotometric assays for urea and creatinine measurements in saliva of dogs showed intra- and inter-assay imprecision lower than 12% and coefficients of correlation close to 1 in linearity under dilution tests. Healthy dogs showed median salivary concentrations of urea of 39.6 mg/dL and creatinine of 0.30 mg/dL, whereas dogs with CKD showed median salivary urea of 270.1 mg/dL and creatinine of 1.86 mg/dL. Positive high correlations were found between saliva and serum activities of the two analytes (urea, r = 0.909; P < 0.001; creatinine, r = 0.819; P < 0.001). CONCLUSIONS: Urea and creatinine concentrations can be measured in canine saliva with commercially available spectrophotometric assays. Both analytes showed higher values in saliva of dogs with CKD compared with healthy dogs and their values were highly correlated with those in serum in our study conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Urea / Creatinina / Enfermedades de los Perros / Perros Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Urea / Creatinina / Enfermedades de los Perros / Perros Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido