Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells.

Li, Huiwen; Yu, Shukui; Hao, Fei; Sun, Xiaohong; Zhao, Junpeng; Xu, Qunyuan; Duan, Deyi

Li, Huiwen; Yu, Shukui; Hao, Fei; Sun, Xiaohong; Zhao, Junpeng; Xu, Qunyuan; Duan, Deyi.

Afiliación

Li H; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Yu S; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Hao F; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Sun X; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Zhao J; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Xu Q; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Duan D; Department of Neurobiology, Beijing Center of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Laboratory of Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.

Cell Biochem Funct ; 36(6): 331-341, 2018 Aug.

Article en En | MEDLINE | ID: mdl-30028031

Asunto(s)

Diferenciación Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Proteína 4 de Unión a Factor de Crecimiento Similar a la Insulina/farmacología; Animales; Células de la Médula Ósea/citología; Células Cultivadas; Factor de Crecimiento Epidérmico/farmacología; Factor 2 de Crecimiento de Fibroblastos/farmacología; Proteína 4 de Unión a Factor de Crecimiento Similar a la Insulina/genética; Proteína 4 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo; Células Madre Mesenquimatosas/citología; Células Madre Mesenquimatosas/efectos de los fármacos; Células Madre Mesenquimatosas/metabolismo; Microscopía Fluorescente; Células-Madre Neurales/citología; Células-Madre Neurales/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas; Ratas Sprague-Dawley; Receptor IGF Tipo 1/metabolismo; Proteínas Recombinantes/biosíntesis; Proteínas Recombinantes/genética; Proteínas Recombinantes/farmacología; Sulfonamidas/farmacología; Tirfostinos/farmacología; beta Catenina/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

bone marrow mesenchymal stem cells; insulin-like growth factor I receptor; insulin-like growth factor binding protein-4; neural progenitor-like cells; proliferation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Proteína 4 de Unión a Factor de Crecimiento Similar a la Insulina / Proliferación Celular Límite: Animals Idioma: En Revista: Cell Biochem Funct Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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