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Human Motor Thalamus Reconstructed in 3D from Continuous Sagittal Sections with Identified Subcortical Afferent Territories.
Ilinsky, Igor; Horn, Andreas; Paul-Gilloteaux, Perrine; Gressens, Pierre; Verney, Catherine; Kultas-Ilinsky, Kristy.
Afiliación
  • Ilinsky I; Unité 1141 Institut National de la Santé et de la Recherche Médicale, UMRS 1141, Hôpital Robert Debré, Paris, Université Paris Diderot, Sorbonne Paris Cité, Paris France.
  • Horn A; The University of Iowa, Iowa City, IA 52242.
  • Paul-Gilloteaux P; Movement Disorders and Neuromodulation Unit, Charité-University Medicine, Berlin 10967, Germany.
  • Gressens P; Unité Mixte de Recherche 144, PICT IBISA Institute Curie, Centre National de la Recherche Scientifique, Paris 75005, France.
  • Verney C; Unité 1141 Institut National de la Santé et de la Recherche Médicale, UMRS 1141, Hôpital Robert Debré, Paris, Université Paris Diderot, Sorbonne Paris Cité, Paris France.
  • Kultas-Ilinsky K; Unité 1141 Institut National de la Santé et de la Recherche Médicale, UMRS 1141, Hôpital Robert Debré, Paris, Université Paris Diderot, Sorbonne Paris Cité, Paris France.
eNeuro ; 5(3)2018.
Article en En | MEDLINE | ID: mdl-30023427
Classification and delineation of the motor-related nuclei in the human thalamus have been the focus of numerous discussions for a long time. Difficulties in finding consensus have for the most part been caused by paucity of direct experimental data on connections of individual nuclear entities. Kultas-Ilinsky et al. (2011) showed that distribution of glutamic acid decarboxylase isoform 65 (GAD65), the enzyme that synthesizes inhibitory neurotransmitter γ-aminobutyric acid, is a reliable marker that allows to delineate connectionally distinct nuclei in the human motor thalamus, namely the territories innervated by nigral, pallidal, and cerebellar afferents. We compared those immunocytochemical staining patterns with underlying cytoarchitecture and used the latter to outline the three afferent territories in a continuous series of sagittal Nissl-stained sections of the human thalamus. The 3D volume reconstructed from the outlines was placed in the Talairach stereotactic coordinate system relative to the intercommissural line and sectioned in three stereotactic planes to produce color-coded nuclear maps. This 3D coordinate-based atlas was coregistered to the Montreal Neurological Institute (MNI-152) space. The current report proposes a simplified nomenclature of the motor-related thalamic nuclei, presents images of selected histological sections and stereotactic maps illustrating topographic relationships of these nuclei as well as their relationship with adjacent somatosensory afferent region. The data are useful in different applications such as functional MRI and diffusion tractography. The 3D dataset is publicly available under an open license and can also be applicable in clinical interventions in the thalamus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Imagenología Tridimensional Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: ENeuro Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Imagenología Tridimensional Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: ENeuro Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos