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Change in biomarkers of type-2 inflammation following severe exacerbations of asthma.
Semprini, Ruth; Shortt, Nick; Ebmeier, Stefan; Semprini, Alex; Varughese, Rachel; Holweg, Cecile T J; Matthews, John G; Fingleton, James; Weatherall, Mark; Beasley, Richard; Braithwaite, Irene.
Afiliación
  • Semprini R; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Shortt N; Victoria University Wellington, Wellington, New Zealand.
  • Ebmeier S; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Semprini A; Victoria University Wellington, Wellington, New Zealand.
  • Varughese R; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Holweg CTJ; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Matthews JG; Victoria University Wellington, Wellington, New Zealand.
  • Fingleton J; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Weatherall M; Genentech Inc, South San Francisco, California, USA.
  • Beasley R; Genentech Inc, South San Francisco, California, USA.
  • Braithwaite I; Medical Research Institute of New Zealand, Wellington, New Zealand.
Thorax ; 74(1): 95-98, 2019 01.
Article en En | MEDLINE | ID: mdl-30021810
We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×109/L, p<0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p<0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p<0.001). A delay of 4-8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma. TRIAL REGISTRATION NUMBER: Post-results; The Australia New Zealand Trial Registry, >ACTRN12614000443695.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Inmunoglobulina E / Moléculas de Adhesión Celular / Eosinófilos / Brote de los Síntomas Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Thorax Año: 2019 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Inmunoglobulina E / Moléculas de Adhesión Celular / Eosinófilos / Brote de los Síntomas Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Thorax Año: 2019 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido