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Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome.
Turhan, Ali Haydar; Atici, Aytug; Sürmeli, Serra.
Afiliación
  • Turhan AH; Associate Professor, Department of Pediatrics, Division of Neonatology, School of Medicine, University of Baskent, Istanbul, Turkey. Scientific, intellectual, conception and design of the study; acquisition of data, analysis and interpretation of data; technical procedures; statistics analysis; manuscript preparation and writing.
  • Atici A; Professor, Department of Pediatrics, Division of Neonatology, School of Medicine, University of Mersin, Turkey. Scientific and intellectual content of the study, manuscript preparation.
  • Sürmeli S; MD, Department of Pediatrics, Division of Neonatology, School of Medicine, University of Mersin, Turkey. Acquisition, analysis and interpretation of data; technical procedures.
Acta Cir Bras ; 33(6): 483-490, 2018 Jun.
Article en En | MEDLINE | ID: mdl-30020309
PURPOSE: To evaluate the effects of hypothermia treatment on meconium-induced inflammation. METHODS: Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1ß, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed. RESULTS: The BAL fluid TNF-α, IL-1ß, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). CONCLUSION: Meconium-induced inflammatory cytokine production is affected by the body temperature control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Síndrome de Aspiración de Meconio / Hipotermia Inducida Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2018 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Síndrome de Aspiración de Meconio / Hipotermia Inducida Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2018 Tipo del documento: Article Pais de publicación: Brasil