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Effects of Mechanical Insufflation-Exsufflation on Airway Mucus Clearance Among Mechanically Ventilated ICU Subjects.
Ferreira de Camillis, Márcio Luiz; Savi, Augusto; Goulart Rosa, Regis; Figueiredo, Mariana; Wickert, Ricardo; Borges, Luis Guilherme Alegretti; Galant, Lucas; Teixeira, Cassiano.
Afiliación
  • Ferreira de Camillis ML; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Savi A; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Goulart Rosa R; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Figueiredo M; Intensive Care Unit, Hospital Santa Clara, Complexo Hospitalar Santa Casade Misericórdia de Porto Alegre, Centro Histórico, Porto Alegre, Brazil.
  • Wickert R; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Borges LGA; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Galant L; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
  • Teixeira C; Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil. cassiano.rush@gmail.com.
Respir Care ; 63(12): 1471-1477, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30018175
BACKGROUND: Few studies have evaluated the effects of mechanical insufflation-exsufflation (MI-E) in subjects on mechanical ventilation. Therefore, this study aimed to evaluate the effectiveness of MI-E on airway mucus clearance among mechanically ventilated ICU subjects. METHODS: A randomized, parallel-group, open-label trial was conducted between June and November 2017 in a single, mixed ICU. Adult ICU subjects receiving mechanical ventilation for > 24 h with stable ventilatory and hemodynamic status were randomized to receive either standard respiratory physiotherapy alone (control group) or respiratory physiotherapy by using an MI-E device (intervention group). The primary outcome was the weight of aspirated airway mucus after study interventions. Secondary outcomes included variation in static lung compliance (ΔCL), airway resistance (ΔRaw), work of breathing (ΔWOB) in relation to the pre-intervention period, and hemodynamic and ventilator complications during the procedures. RESULTS: There were 90 subjects in each group. The mean ± SD weight of the aspirated airway mucus was higher in the intervention group than in the control group (2.42 ± 2.32 g vs 1.35 ± 1.56 g, P < .001). The ΔCL values in the intervention group were higher than those in the control group (1.76 ± 4.90 mL/cm H2O vs -0.57 ± 4.85 mL/cm H2O, P = .001). The ΔRaw and ΔWOB values were similar between the groups. No hemodynamic or ventilatory complications were observed. CONCLUSIONS: Among the general ICU subjects receiving mechanical ventilation, use of an MI-E device during respiratory physiotherapy resulted in a larger amount of airway mucus clearance than respiratory physiotherapy alone. (ClinicalTrials.gov registration NCT03178565.).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Respiración Artificial / Terapia Respiratoria / Depuración Mucociliar / Moco Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Care Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Respiración Artificial / Terapia Respiratoria / Depuración Mucociliar / Moco Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Care Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos