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A pilot investigation of differential neuroendocrine associations with fronto-limbic activation during semantically-cued list learning in mood disorders.
Peters, A T; Smith, R A; Kassel, M T; Hagan, M; Maki, P; Van Meter, A; Briceño, E M; Ryan, K A; Weldon, A L; Weisenbach, S L; Starkman, M N; Langenecker, S A.
Afiliación
  • Peters AT; Department of Psychiatry, University of Illinois at Chicago, USA.
  • Smith RA; Department of Psychiatry, University of Illinois at Chicago, USA.
  • Kassel MT; Department of Psychology, University of Wisconsin-Milwaukee, USA.
  • Hagan M; Department of Psychology, San Francisco State University, USA; Department of Psychiatry, University of California, San Francisco, USA.
  • Maki P; Department of Psychiatry, University of Illinois at Chicago, USA.
  • Van Meter A; Department of Psychiatry Research, The Feinstein Institute for Medical Research, Zucker Hillside Hospital, USA.
  • Briceño EM; Department of Psychiatry, University of Michigan Medical Center, USA.
  • Ryan KA; Department of Psychiatry, University of Michigan Medical Center, USA.
  • Weldon AL; Department of Psychology, University of Illinois Urbana-Champaign, USA.
  • Weisenbach SL; Department of Psychiatry, University of Utah, USA; VA Salt Lake City Healthcare System, USA.
  • Starkman MN; Department of Psychiatry, University of Michigan Medical Center, USA.
  • Langenecker SA; Department of Psychiatry, University of Illinois at Chicago, USA. Electronic address: slangenecker@psych.uic.edu.
J Affect Disord ; 239: 180-191, 2018 10 15.
Article en En | MEDLINE | ID: mdl-30014958
BACKGROUND: Decreased volume and disrupted function in neural structures essential for memory formation (e.g. medial temporal lobe and prefrontal cortex) are common among individuals with depression. Hypothalamic-pituitary-axis function, as reflected by measurement of cortisol levels, is linked to neural activity during memory encoding in healthy people. However, it is not as well understood whether cortisol is associated with alterations in fronto-temporal recruitment during memory encoding in depression. METHODS: In this pilot study, we evaluated associations between cortisol and neural activation during memory encoding in 62 adults (18-65 years) with mood disorders (MD; n = 39, 66.7% female), including major depression (n = 28) and bipolar I disorder (n = 11), and healthy controls (HC; n = 23, 43.5% female). Participants provided salivary cortisol samples before and after completing a semantically-cued list-learning task during 3-Tesla fMRI. Links between pre-scan cortisol (and cortisol change) and activation during encoding were evaluated using block and event-related models. RESULTS: Overall, pre-scan cortisol level was positively associated with greater engagement of fronto-limbic activation during the encoding block. However, in MD, pre-scan cortisol was associated with attenuated activation during encoding in medial frontal, superior and middle temporal gyri, insula, lingual gyrus, and claustrum relative to HCs. Cortisol-related attenuation of activation in MD was also observed during encoding of words subsequently recalled in the ventral anterior cingulate, hypothalamus, and middle temporal gyrus. By and large, cortisol change (pre/post scan) predicted the same pattern of findings in both block and event-related contrasts. LIMITATIONS: Although analyses accounted for variations in scanner time of day, circadian alterations in cortisol may have introduced variability into the results. CONCLUSIONS: Pre-scan cortisol may selectively interfere with recruitment of important fronto-temporal memory circuitry in mood disorders. The inverted associations between cortisol and neural function in MD relative to HC also elucidate potentially unique pathophysiological markers of mood disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aprendizaje por Asociación / Trastorno Bipolar / Encéfalo / Hidrocortisona / Trastorno Depresivo Mayor Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Affect Disord Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aprendizaje por Asociación / Trastorno Bipolar / Encéfalo / Hidrocortisona / Trastorno Depresivo Mayor Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Affect Disord Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos