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Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria).
Mulwa, Lucky S; Jansen, Rolf; Praditya, Dimas F; Mohr, Kathrin I; Okanya, Patrick W; Wink, Joachim; Steinmann, Eike; Stadler, Marc.
Afiliación
  • Mulwa LS; Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • Jansen R; Work group Microbial Strain Collection (MISG), Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • Praditya DF; Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • Mohr KI; TWINCORE-Centre for Experimental and Clinical Infection Research (Institute of Experimental Virology) Hannover. Feodor-Lynen-Str. 7-9, 30625 Hannover, Germany. Tel: +49(0)511-220027-133.
  • Okanya PW; Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • Wink J; Work group Microbial Strain Collection (MISG), Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • Steinmann E; Department of Biochemistry and Biotechnology, The Technical University of Kenya, P.O. Box 52428 - 00200, Located along Haile Selassie Avenue, Nairobi, Kenya. Tel: +254(020) 2219929.
  • Stadler M; Work group Microbial Strain Collection (MISG), Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Beilstein J Org Chem ; 14: 1554-1562, 2018.
Article en En | MEDLINE | ID: mdl-30013682
Lanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned based on NOE and vicinal 1H NMR coupling constants and by calculation of a 3D model. Lanyamycin inhibited HCV infection into mammalian liver cells with an IC50 value of 11.8 µM, and exhibited a moderate cytotoxic activity against the mouse fibroblast cell line L929 and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 µM, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania