Models for Nociception Stimulation and Memory Effects in Awake and Aware Healthy Individuals.
IEEE Trans Biomed Eng
; 66(3): 718-726, 2019 03.
Article
en En
| MEDLINE
| ID: mdl-30010543
OBJECTIVE: This paper introduces a primer in the health care practice, namely a mathematical model and methodology for detecting and analysing nociceptor stimulation followed by related tissue memory effects. METHODS: Noninvasive nociceptor stimulus protocol and prototype device for measuring bioimpedance is provided. Various time instants, sensor location, and stimulus train have been analysed. RESULTS: The method and model indicate that nociceptor stimulation perceived as pain in awake healthy volunteers is noninvasively detected. The existence of a memory effect is proven from data. Sensor location had minimal effect on detection level, while day-to-day variability was observed without being significant. CONCLUSION: Following the experimental study, the model enables a comprehensive management of chronic pain patients, and possibly other analgesia, or pain related regulatory loops. SIGNIFICANCE: A device and methodology for noninvasive for detecting nociception stimulation have been developed. The proposed method and models have been validated on healthy volunteers.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Vigilia
/
Procesamiento de Señales Asistido por Computador
/
Impedancia Eléctrica
/
Nocicepción
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Estados Unidos