Your browser doesn't support javascript.
loading
An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo.
Zhang, Wen; De La Vega, Rodolfo E; Coenen, Michael J; Müller, Sebastian A; Peniche Silva, Carlos J; Aneja, Manish K; Plank, Christian; van Griensven, Martijn; Evans, Christopher H; Balmayor, Elizabeth R.
Afiliación
  • Zhang W; 1 Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • De La Vega RE; 2 Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Coenen MJ; 3 Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota.
  • Müller SA; 3 Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota.
  • Peniche Silva CJ; 3 Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota.
  • Aneja MK; 4 Department of Orthopedic Surgery, University of Basel, Basel, Switzerland.
  • Plank C; 1 Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • van Griensven M; 5 Ethris GmbH, Planegg, Germany.
  • Evans CH; 2 Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Balmayor ER; 5 Ethris GmbH, Planegg, Germany.
Tissue Eng Part A ; 25(1-2): 131-144, 2019 01.
Article en En | MEDLINE | ID: mdl-30009674
IMPACT STATEMENT: The use of chemically modified RNA (cmRNA) with increased stability using translation initiator of short untranslated regions (TISU) offers the prospect of finally allowing us to unlock the potent osteogenic properties of BMP-2 in a clinically expedient manner. As noted, delivery of recombinant BMP-2 protein has had modest clinical efficacy, whereas gene delivery is effective but very difficult to translate into human clinical use. This study shows the great potential of cmRNA encoding BMP-2 with TISU in a long-bone critical-sized rat model.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / ARN Mensajero / Técnicas de Transferencia de Gen / Proteína Morfogenética Ósea 2 / Células Madre Mesenquimatosas Límite: Animals / Humans / Male Idioma: En Revista: Tissue Eng Part A Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / ARN Mensajero / Técnicas de Transferencia de Gen / Proteína Morfogenética Ósea 2 / Células Madre Mesenquimatosas Límite: Animals / Humans / Male Idioma: En Revista: Tissue Eng Part A Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos