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Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.
Zak, Joseph D; Grimaud, Julien; Li, Rong-Chang; Lin, Chih-Chun; Murthy, Venkatesh N.
Afiliación
  • Zak JD; Department of Molecular and Cellular Biology & Center for Brain Science, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA.
  • Grimaud J; Department of Molecular and Cellular Biology & Center for Brain Science, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA.
  • Li RC; Molecules, Cells & Organisms Program, Harvard University, Cambridge, 02138, MA, USA.
  • Lin CC; Johns Hopkins University School of Medicine, Preclinical Teaching Building Room 905A, 725 North Wolfe Street, MD, 21205, Baltimore, USA.
  • Murthy VN; Johns Hopkins University School of Medicine, Preclinical Teaching Building Room 905A, 725 North Wolfe Street, MD, 21205, Baltimore, USA.
Sci Rep ; 8(1): 10600, 2018 Jul 13.
Article en En | MEDLINE | ID: mdl-30006552
The calcium-activated chloride channel anoctamin-2 (Ano2) is thought to amplify transduction currents in olfactory receptor neurons (ORNs), a hypothesis supported by previous studies in dissociated neurons from Ano2-/- mice. Paradoxically, despite a reduction in transduction currents in Ano2-/- ORNs, their spike output for odor stimuli may be higher. We examined the role of Ano2 in ORNs in their native environment in freely breathing mice by imaging activity in ORN axons as they arrive in the olfactory bulb glomeruli. Odor-evoked responses in ORN axons of Ano2-/- animals were consistently larger for a variety of odorants and concentrations. In an open arena, Ano2-/- animals took longer to approach a localized odor source than Ano2+/+ animals, revealing clear olfactory behavioral deficits. Our studies provide the first in vivo evidence toward an alternative or additional role for Ano2 in the olfactory transduction cascade, where it may serve as a feedback mechanism to clamp ORN spike output.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Olfato / Neuronas Receptoras Olfatorias / Potenciales Evocados Somatosensoriales / Anoctaminas Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Olfato / Neuronas Receptoras Olfatorias / Potenciales Evocados Somatosensoriales / Anoctaminas Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido