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Multiscale Computational Analysis of Right Ventricular Mechanoenergetics.
Pewowaruk, Ryan J; Philip, Jennifer L; Tewari, Shivendra G; Chen, Claire S; Nyaeme, Mark S; Wang, Zhijie; Tabima, Diana M; Baker, Anthony J; Beard, Daniel A; Chesler, Naomi C.
Afiliación
  • Pewowaruk RJ; Mem. ASME Biomedical Engineering, University of Wisconsin-Madison, 2145 Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail: .
  • Philip JL; Surgery, University of Wisconsin-Madison, , 1550 Engineering Drive, Madison, WI 53706 e-mail: .
  • Tewari SG; Molecular & Integrative Physiology, University of Michigan-Ann Arbor, , North Campus Research Center, Ann Arbor, MI 48109-5622 e-mail: .
  • Chen CS; Mechanical Engineering, University of Wisconsin-Madison, , 1550 Engineering Drive, Madison, WI 53706 e-mail: .
  • Nyaeme MS; Biomedical Engineering, University of Wisconsin-Madison, , 1550 Engineering Drive, Madison, WI 53706 e-mail: .
  • Wang Z; Mechanical Engineering, Colorado State University, , Fort Collins, CO 80521 e-mail: .
  • Tabima DM; Biomedical Engineering, University of Wisconsin-Madison, , 1550 Engineering Drive, Madison, WI 53706 e-mail: .
  • Baker AJ; Medicine, University of California-San Francisco, , San Francisco, CA 94121; VA Medical Center, 4150 Clement St., San Francisco, CA 94121 e-mail: .
  • Beard DA; Molecular & Integrative Physiology, University of Michigan-Ann Arbor, , North Campus Research Center, Ann Arbor, MI 48109-5622 e-mail: .
  • Chesler NC; Fellow ASME Biomedical Engineering, University of Wisconsin-Madison Medicine, , 1550 Engineering Drive, Madison, WI 53706 e-mail: .
J Biomech Eng ; 140(8)2018 08 01.
Article en En | MEDLINE | ID: mdl-30003251
Right ventricular (RV) failure, which occurs in the setting of pressure overload, is characterized by abnormalities in mechanical and energetic function. The effects of these cell- and tissue-level changes on organ-level RV function are unknown. The primary aim of this study was to investigate the effects of myofiber mechanics and mitochondrial energetics on organ-level RV function in the context of pressure overload using a multiscale model of the cardiovascular system. The model integrates the mitochondria-generated metabolite concentrations that drive intracellular actin-myosin cross-bridging and extracellular myocardial tissue mechanics in a biventricular heart model coupled with simple lumped parameter circulations. Three types of pressure overload were simulated and compared to experimental results. The computational model was able to capture a wide range of cardiovascular physiology and pathophysiology from mild RV dysfunction to RV failure. Our results confirm that, in response to pressure overload alone, the RV is able to maintain cardiac output (CO) and predict that alterations in either RV active myofiber mechanics or RV metabolite concentrations are necessary to decrease CO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenómenos Mecánicos / Ventrículos Cardíacos / Modelos Cardiovasculares Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biomech Eng Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenómenos Mecánicos / Ventrículos Cardíacos / Modelos Cardiovasculares Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biomech Eng Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos