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True hypopharyngeal carcinosarcoma: a case report and literature review.
Zhong, Jiang-Tao; Xie, Xiao-Xing; Zhou, Shui-Hong; Yao, Hong-Tian; Chen, Zhe; Wu, Ting-Ting; Bao, Yang-Yang; Yu, Qi; Han, He-Ming.
Afiliación
  • Zhong JT; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Xie XX; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Zhou SH; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Yao HT; 2 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Pathology, Zhejiang, China.
  • Chen Z; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Wu TT; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Bao YY; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Yu Q; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
  • Han HM; 1 The First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Otolaryngology, Zhejiang, China.
J Int Med Res ; 46(8): 3446-3461, 2018 Aug.
Article en En | MEDLINE | ID: mdl-29996673
Objective Carcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx. Methods A 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) showed a neoplasm on the left posterior hypopharyngeal wall. The patient underwent bilateral neck dissection and excision of the hypopharyngeal cancer followed by postoperative radiation therapy. Results Immunohistochemistry revealed carcinomatous cells with membrane positivity for cytokeratin, glucose transporter-1 (GLUT-1), phosphoinositide-3 kinase (PI3K), hypoxia-inducible factor-1α (HIF-1α), and hexokinase-II as well as sarcomatous cells with membrane positivity for smooth muscle actin, GLUT-1, HIF-1α, and PI3K. Histopathology and immunohistochemistry revealed a true carcinosarcoma of the hypopharynx (pT3N0M0, Stage III). Conclusions Thorough immunohistochemistry is required for a correct diagnosis of hypopharyngeal carcinosarcoma. 18F-FDG PET/CT may help to distinguish hypopharyngeal carcinosarcoma from benign tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinosarcoma / Neoplasias Hipofaríngeas Límite: Aged / Humans / Male Idioma: En Revista: J Int Med Res Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinosarcoma / Neoplasias Hipofaríngeas Límite: Aged / Humans / Male Idioma: En Revista: J Int Med Res Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido