Histidine catabolism is a major determinant of methotrexate sensitivity.

Kanarek, Naama; Keys, Heather R; Cantor, Jason R; Lewis, Caroline A; Chan, Sze Ham; Kunchok, Tenzin; Abu-Remaileh, Monther; Freinkman, Elizaveta; Schweitzer, Lawrence D; Sabatini, David M

Kanarek, Naama; Keys, Heather R; Cantor, Jason R; Lewis, Caroline A; Chan, Sze Ham; Kunchok, Tenzin; Abu-Remaileh, Monther; Freinkman, Elizaveta; Schweitzer, Lawrence D; Sabatini, David M.

Afiliación

Kanarek N; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Keys HR; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cantor JR; Koch Institute for Integrative Cancer Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Lewis CA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Chan SH; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Kunchok T; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Abu-Remaileh M; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Freinkman E; Koch Institute for Integrative Cancer Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
Schweitzer LD; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Sabatini DM; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.

Nature ; 559(7715): 632-636, 2018 07.

Article en En | MEDLINE | ID: mdl-29995852

Asunto(s)

Histidina/metabolismo; Metotrexato/farmacología; Metotrexato/uso terapéutico; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Amoníaco-Liasas/deficiencia; Amoníaco-Liasas/genética; Amoníaco-Liasas/metabolismo; Animales; Sistemas CRISPR-Cas/genética; Línea Celular Tumoral; Femenino; Antagonistas del Ácido Fólico/farmacología; Antagonistas del Ácido Fólico/uso terapéutico; Glutamato Formimidoiltransferasa/deficiencia; Glutamato Formimidoiltransferasa/genética; Glutamato Formimidoiltransferasa/metabolismo; Histidina/farmacología; Humanos; Masculino; Ratones; Ratones Endogámicos NOD; Ratones SCID; Enzimas Multifuncionales; Nucleótidos/biosíntesis; Proteína Portadora de Folato Reducido/genética; Proteína Portadora de Folato Reducido/metabolismo; Tetrahidrofolato Deshidrogenasa/metabolismo; Tetrahidrofolatos/deficiencia; Tetrahidrofolatos/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metotrexato / Histidina / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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