Increased separability of K-edge nanoparticles by photon-counting detectors for spectral micro-CT.
J Xray Sci Technol
; 26(5): 707-726, 2018.
Article
en En
| MEDLINE
| ID: mdl-29991154
BACKGROUND: X-ray CT/micro-CT methods with photon-counting detectors (PCDs) and high Z materials are a hot research topic. One method using PCDs allows for spectral imaging in 5 energy windows while conventional X-ray detectors only collect energy-integrating data. OBJECTIVE: To demonstrate the enhanced separation of contrast materials by using PCDs, multivariate analysis, and linear discriminant methods. METHODS: Phantoms containing iodine and aqueous nanomaterials were scanned on a MARS spectral micro-CT. Image volumes were segmented into separate material-specific populations. Contrast comparisons were made by calculating T2 test statistics in the univariate, pseudo-conventional and multivariate, spectral CT data sets. Separability after Fisher discriminant analysis (FDA) was also assessed. RESULTS: The T2 values calculated for material comparisons increased as a result of the spectral expansion. The majority of the tested contrast agents showed increased T2 values by a factor of â¼2 -3. The total significant T2 statistics in the pure and mixed lanthanide image sets increased in the spectral data set. CONCLUSION: This work consolidates the groundwork for photon-counting-based material decomposition with micro-CT, facilitating future development of novel nanomaterials and their preclinical applications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nanopartículas
/
Microtomografía por Rayos X
Idioma:
En
Revista:
J Xray Sci Technol
Asunto de la revista:
RADIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos